Acquired 'Phase Separation' Underlies Aberrant Cell Fate Control?

Cell Differentiation Chromatin Gain of Function Mutation Mutation
abnormal condensates chromatin readers eleven-nineteen-leukemia protein

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
06 2020
Historique:
received: 01 02 2020
revised: 08 02 2020
accepted: 13 02 2020
entrez: 16 5 2020
pubmed: 16 5 2020
medline: 12 2 2021
Statut: ppublish

Résumé

Chromatin readers are important intermediaries linking epigenetic information and biological phenotypes. Many diseases are caused by mutations in epigenetic readers. Recently, a study by Wan et al. uncovered that cancer-associated mutations promote self-association of eleven-nineteen-leukemia protein (ENL), leading to abnormal condensates, elevated gene expression, and impaired cell fate determination.

Identifiants

DOI: 10.1016/j.tibs.2020.02.007 PMID: 32413321
pubmed: 32413321
pii: S0968-0004(20)30053-0
doi: 10.1016/j.tibs.2020.02.007
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

457-458

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Yifei Gao (Y)

Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Pilong Li (P)

Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: pilongli@mail.tsinghua.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Acquired 'Phase Separation' Underlies Aberrant...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Acquired 'Phase Separation' Underlies Aberrant...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation gain de fonction › Acquired 'Phase Separation' Underlies Aberrant...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Acquired 'Phase Separation' Underlies Aberrant...