Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity.
CYPs
biocatalysis
drug leads
late-stage functionalization
natural products
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
17
12
2019
revised:
28
02
2020
accepted:
06
03
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
The design of drugs from natural products is a re-emerging area due to the need for bioactive compounds. The exploitation of natural products and their derivatives obtained by biocatalysis is in line with the higher attention given today to new sustainable technologies that better preserve the environment (green chemistry). The research field of cytochromes P450 (CYPs) is continuously providing new enzymes and mutants that produce metabolites suitable for late-stage functionalization for new potential drugs. This review provides an overview of the exploitation of CYPs as biocatalysts in drug synthesis. Additionally, recent progress in protein and metabolic engineering is provided to show how these enzymes offer a toolbox that can be combined with other biocatalytic or chemical processes to build new platforms for the green production of new drugs.
Identifiants
pubmed: 32413326
pii: S0968-0004(20)30062-1
doi: 10.1016/j.tibs.2020.03.004
pii:
doi:
Substances chimiques
Biological Products
0
Pharmaceutical Preparations
0
Cytochrome P-450 Enzyme System
9035-51-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
511-525Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.