The frequency of pulmonary hypertension in newborn with intrauterine growth restriction.
Birth Weight
Case-Control Studies
Cross-Sectional Studies
Female
Fetal Growth Retardation
/ physiopathology
Gestational Age
Humans
Hypertension, Pulmonary
/ epidemiology
Infant, Newborn
Infant, Premature, Diseases
/ epidemiology
Infant, Small for Gestational Age
Male
Pakistan
/ epidemiology
Pregnancy
Prevalence
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
08
10
2019
accepted:
22
04
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Intrauterine growth restriction (IUGR) is a clinical definition applied to neonates born with clinical features of malnutrition and in-utero growth retardation irrespective of their birth weight percentile. This study was aimed to determine the frequency of pulmonary hypertension (PH) in neonates with IUGR. In this descriptive cross-sectional study, we followed 96 neonates with IUGR (≤28 days) and 38 neonates without IUGR born in the department of the neonatal intensive care unit children hospital complex Multan, Pakistan. We analyzed certain factors such as gender, gestational age (GA) (weeks), birth weight (BW in kg), weight percentile (WP) for GA, meconium aspiration syndrome (MAS), birth asphyxia (BA) and respiratory distress syndrome (RDS) for pulmonary hypertension (PH) in IUGR and non-IUGR group. GA was measured by the Ballard scoring system. Echocardiography was performed for all patients by the pediatric cardiologist to measure pulmonary arterial (PA) pressure using Bernoulli's equation. Out of total 96 IUGR neonates, 33.3% (n = 32) suffered from PH, of which 65.3% (n = 18) were male and 43.7% (n = 14) were female. The percentages of IUGR neonates with BA, MAS and RDS were 34.4%, 18.8% and 22.9% respectively. The data were analyzed using the SPSS-16 software to test the statistical significance of the results. A p-value less than 0.05 was considered significant. When the chi-square test was applied, it depicted that MAS was significantly associated with PH in IUGR neonates (p = 0.0001) compared to non-IUGR neonates. Our findings suggested an increased chance of PH in IUGR neonates and MAS may be a strong factor.
Identifiants
pubmed: 32415157
doi: 10.1038/s41598-020-65065-2
pii: 10.1038/s41598-020-65065-2
pmc: PMC7229189
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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