Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy: Experience of 109 cases.
anti-reflux mucosectomy
endoscopic mucosal resection
gastroesophageal reflux disease
proton pump inhibitor
Journal
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
ISSN: 1443-1661
Titre abrégé: Dig Endosc
Pays: Australia
ID NLM: 9101419
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
18
02
2020
revised:
11
05
2020
accepted:
11
05
2020
pubmed:
18
5
2020
medline:
29
7
2021
entrez:
17
5
2020
Statut:
ppublish
Résumé
Some patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) therapy. Anti-reflux mucosectomy (ARMS) is a minimally invasive endoscopic procedure for treatment of GERD. In this study, we retrospectively evaluated the outcomes of ARMS performed in patients with PPI-refractory GERD at our institution. A total of 109 patients with PPI-refractory GERD who underwent ARMS were retrospectively reviewed. Pre- and post-ARMS questionnaire scores, acid exposure time (AET), DeMeester score, proximal extent, and PPI discontinuation rate were compared. There was a significant improvement in the symptom score (P < 0.01) and 40-50% of patients were able to discontinue PPI after ARMS. In patients who were followed up for 3 years, sustained improvement in subjective symptoms was observed. AET and DeMeester score significantly improved after ARMS (P < 0.01); however, there was no significant improvement in proximal extent (P = 0.0846). Anti-reflux mucosectomy is an effective minimally invasive therapy for patients with PPI-refractory GERD. The therapeutic efficacy is attributable to suppression of acid backflow due to contraction of the scar tissue in cardia.
Substances chimiques
Proton Pump Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
347-354Informations de copyright
© 2020 Japan Gastroenterological Endoscopy Society.
Références
Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol 2009; 44: 518-34.
Toghanian S, Johnson DA, Stålhammar NO et al. Burden of gastro-oesophageal reflux disease in patients with persistent and intense symptoms despite proton pump inhibitor therapy: A post hoc analysis of the 2007 national health and wellness survey. Clin Drug Investig 2011; 31: 703-15.
Fass R, Shapiro M, Dekel R et al. Systematic review: Proton-pump inhibitor failure in gastro-oesophageal reflux disease-where next? Aliment Pharmacol Ther 2005; 22: 79-94.
Yadlapati R, Hungness ES, Pandolfino JE. Complications of antireflux surgery. Am J Gastroenterol 2018; 113: 1137-47.
Bonavina L, Saino G, Lipham JC et al. LINX® Reflux management system in chronic gastroesophageal reflux: A novel effective technology for restoring the natural barrier to reflux. Ther Adv Gastroenterol 2013; 6: 261-8.
Cadière GB, Rajan A, Rqibate M et al. Endoluminal fundoplication (ELF) - evolution of EsophyX, a new surgical device for transoral surgery. Minim Invas Ther Allied Technol 2006; 15: 348-55.
Yeh RW, Triadafilopoulos G. Endoscopic antireflux therapy: The Stretta procedure. Thorac Surg Clin 2005; 15: 395-403.
Toshitaka H, Rodríguez L, Soffer E et al. Long-term results of electorical stimulation of the lower esophageal sphincter for treatment of proximal. Surg Endosc 2014; 28: 3293-301.
Hillman L, Yadlapati R, Whitsett M et al. Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease. Dis Esophagus 2017; 30: 1-14.
Satodate H, Inoue H, Fukami N et al. Squamous reepithelialization after circumferential endoscopic mucosal resection of superficial carcinoma arising in Barrett’s esophagus. Endoscopy 2004; 36: 909-12.
Inoue H, Ito H, Ikeda H et al. Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: A pilot study. Ann Gastroenterol 2014; 27: 346-51.
Kusano M, Shimoyama Y, Sugimoto S et al. Development and evaluation of FSSG: Frequency scale for the symptoms of GERD. J Gastroenterol 2004; 39: 888-91.
Hongo M, Miwa H, Kusano M et al. Symptoms and quality of life in underweight gastroesophageal reflux disease patients and therapeutic responses to proton pump inhibitors. J Gastroenterol Hepatol 2012; 27: 913-8.
Jones R, Junghard O, Dent J et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther 2009; 30: 1030-8.
Suzuki H, Matsuzaki J, Okada S et al. Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan. U Eur Gastroenterol J 2013; 1: 175-83.
Inoue H, Takeshita K, Hori H et al. Endoscopic mucosal resection with a cap-fitted panendoscope for esophagus, stomach, and colon mucosal lesions. Gastrointest Endosc 1993; 39: 58-62.
Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: Expert review and best practice advice from the American Gastroenterological Association. Gastroenterology 2017; 152: 706-15.
Yoo IK, Ko WJ, Kim HS et al. Anti-reflux mucosectomy using a cap-assisted endoscopic mucosal resection method for refractory gastroesophageal disease: A prospective feasibility study. Surg Endosc 2020; 34: 1124-31.
Patil G, Dalal A, Maydeo A. Feasibility and outcomes of anti-reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video). Dig Endosc 2020; 32: 745-52.
Hedberg HM, Kuchta K, Ujiki MB et al. First experience with banded anti-reflux mucosectomy (ARMS) for GERD: Feasibility, safety, and technique (with Video). J Gastrointest Surg 2019; 23: 1274-8.
Dodds WJ, Dent J, Hogan WJ et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 1982; 307: 1547-52.
Mittal RK, McCallum RW. Characteristics and frequency of transient relaxations of the lower esophageal sphincter in patients with reflux esophagitis. Gastroenterology 1988; 95: 593-9.
Holloway RH, Kocyan P, Dent J. Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastroesophageal reflux. Dig Dis Sci 1991; 36: 1034-9.
Bredenoord AJ, Weusten BL, Curvers WL et al. Determinants of perception of heartburn and regurgitation. Gut 2006; 55: 313-8.
Inoue H, Tanabe M, de Santiago ER et al. Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: A pilot study. Endosc Int Open. 2020; 8: E133-8.
Ota K, Takeuchi T, Harada S et al. A novel endoscopic submucosal dissection technique for proton pump inhibitor-refractory gastroesophageal reflux disease. Scand J Gastroenterol 2014; 49: 1409-13.