Suppressed immune profile in children with combined type 1 diabetes and celiac disease.
Acute-Phase Proteins
/ metabolism
Adolescent
Celiac Disease
/ complications
Chemokine CCL2
/ metabolism
Chemokine CCL3
/ metabolism
Child
Cohort Studies
Diabetes Mellitus, Type 1
/ complications
Female
Fibrinogen
/ metabolism
Humans
Interleukins
/ metabolism
Male
Matrix Metalloproteinase 2
/ metabolism
Nicotinamide Phosphoribosyltransferase
/ metabolism
Procalcitonin
/ metabolism
Th17 Cells
/ immunology
Interleukin-22
celiac disease
children
immune markers
type 1 diabetes
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
21
01
2020
revised:
06
05
2020
accepted:
06
05
2020
pubmed:
18
5
2020
medline:
20
1
2021
entrez:
17
5
2020
Statut:
ppublish
Résumé
Children diagnosed with a combination of type 1 diabetes (T1D) and celiac disease (CD) show a dysregulated T helper type 1 (Th1)/Th17 response. Besides the cellular involvement, several soluble immune markers are involved in the autoimmune process of both T1D and CD. Only few studies have examined the peripheral pattern of different cytokines, chemokines and acute-phase proteins (APP) in children with combined T1D and CD. To our knowledge, no studies have evaluated the serum levels of adipocytokines and matrix metalloproteinases (MMPs) in this context. The purpose of the present study was to acquire more knowledge and to gain deeper understanding regarding the peripheral immunoregulatory milieu in children with both T1D and CD. The study included children diagnosed with both T1D and CD (n = 18), children with T1D (n = 27) or CD (n = 16) and reference children (n = 42). Sera were collected and analysis of 28 immune markers (cytokines, chemokines, APPs, adipocytokines and MMPs) was performed using the Luminex technique. The major findings showed that children with a double diagnosis had lower serum levels of interleukin (IL)-22, monocyte chemoattractant protein (MIP)-1α, monocyte chemoattractant protein (MCP)-1, procalcitonin, fibrinogen, visfatin and matrix metalloproteinase (MMP)-2. These results indicate a suppressed immune profile in children with combined T1D and CD, including Th17 cytokines, chemokines, APPs, adipocytokines and MMPs. We conclude that, besides cytokines and chemokines, other immune markers, e.g. APPs, adipocytokines and MMPs, are of importance for further investigations to elucidate the heterogeneous immune processes present in patients diagnosed with T1D in combination with CD.
Identifiants
pubmed: 32415995
doi: 10.1111/cei.13454
pmc: PMC7419926
doi:
Substances chimiques
Acute-Phase Proteins
0
CCL2 protein, human
0
CCL3 protein, human
0
Chemokine CCL2
0
Chemokine CCL3
0
Interleukins
0
Procalcitonin
0
Fibrinogen
9001-32-5
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
Matrix Metalloproteinase 2
EC 3.4.24.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
244-257Informations de copyright
© 2020 The Authors. Clinical & Experimental Immunology published by John Wiley and Sons Ltd on behalf of British Society for Immunology.
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