Senescent Fibroblast-Derived GDF15 Induces Skin Pigmentation.

Adolescent Adult Aged Biopsy Cells, Cultured Cellular Senescence / radiation effects Child Coculture Techniques Fibroblasts / metabolism Gene Knockdown Techniques Growth Differentiation Factor 15 / genetics Humans Melanins / analysis Melanocytes / metabolism Melanosis / pathology Middle Aged Primary Cell Culture Skin / cytology Skin Aging / physiology Skin Pigmentation / physiology Ultraviolet Rays / adverse effects

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
12 2020
Historique:
received: 28 06 2019
revised: 14 04 2020
accepted: 29 04 2020
pubmed: 18 5 2020
medline: 2 4 2021
entrez: 17 5 2020
Statut: ppublish

Résumé

Senescent fibroblasts play a role in aging pigmentation. In this study, we found that GDF15 expression levels are increased in UV-irradiated senescent fibroblasts and photoaged hyperpigmented skin. To investigate the effects of GDF15 on melanogenesis, normal human melanocytes were cocultured with fibroblasts infected with the GDF15 lentivirus or GDF15 short hairpin RNA. It was found that GDF15 stimulates melanogenesis in melanocytes through MITF/tyrosinase upregulation via β-catenin signaling. The stimulatory action of GDF15 during pigmentation was further confirmed in ex vivo cultured skin and in a reconstituted human skin sample. These results suggest that senescent fibroblast-derived GDF15 stimulates skin pigmentation and may play a role in aging-associated pigmentation.

Identifiants

DOI: 10.1016/j.jid.2020.04.016 PMID: 32416083
pubmed: 32416083
pii: S0022-202X(20)31576-1
doi: 10.1016/j.jid.2020.04.016
pii:
doi:

Substances chimiques

GDF15 protein, human 0
Growth Differentiation Factor 15 0
Melanins 0

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2478-2486.e4

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Yeongeun Kim (Y)

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, The Graduate School, Ajou University, Suwon, Korea.

Bogyeong Kang (B)

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, The Graduate School, Ajou University, Suwon, Korea.

Jin Cheol Kim (JC)

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Tae Jun Park (TJ)

Department of Biomedical Science, The Graduate School, Ajou University, Suwon, Korea; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

Hee Young Kang (HY)

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, The Graduate School, Ajou University, Suwon, Korea. Electronic address: hykang@ajou.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Cellules › Cellules cultivées › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de coculture › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Facteur-15 de croissance et de différenciation › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Mélanines › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Cellules › Cellules épithéliales › Mélanocytes › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Hyperpigmentation › Mélanose › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Système tégumentaire › Peau › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Vieillissement de la peau › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Phénomènes biologiques › Pigmentation › Pigmentation de la peau › Senescent Fibroblast-Derived GDF15 Induces...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Senescent Fibroblast-Derived GDF15 Induces...