Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement.
Aged
Aged, 80 and over
Aortic Valve Stenosis
/ complications
Cross-Sectional Studies
Female
Florida
/ epidemiology
Follow-Up Studies
Health Status
Humans
Male
Muscle, Skeletal
/ diagnostic imaging
Postoperative Period
Prevalence
Quality of Life
Retrospective Studies
Risk Assessment
/ methods
Risk Factors
Sarcopenia
/ diagnosis
Severity of Illness Index
Time Factors
Tomography, X-Ray Computed
Transcatheter Aortic Valve Replacement
Journal
American heart journal
ISSN: 1097-6744
Titre abrégé: Am Heart J
Pays: United States
ID NLM: 0370465
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
31
03
2020
accepted:
31
03
2020
pubmed:
18
5
2020
medline:
17
7
2020
entrez:
17
5
2020
Statut:
ppublish
Résumé
Skeletal muscle wasting, or sarcopenia, affects a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). However, its influence on post-TAVR recovery and 1-year health-related quality of life (HR-QOL) remains unknown. We examined the relationship between skeletal muscle index (SMI), post-TAVR length of hospital stay (LOS), and 1-year QOL. The study sample consisted of 300 consecutive patients undergoing TAVR from 2012 to 2018 who had pre-TAVR computed tomographic scans suitable for analysis of body composition. Skeletal muscle mass was quantified as cm Sarcopenia was present in most (59%) patients and associated with older age (82 vs 76 years; P < .001) and lower body mass index (27 vs 33 kg/m Sarcopenia is prevalent in TAVR patients. Higher SMI is associated with shorter LOS and better 1-year HR-QOL. To achieve optimal TAVR benefits, further study into how body composition influences post-TAVR recovery and durable improvement in QOL is warranted.
Sections du résumé
BACKGROUND
Skeletal muscle wasting, or sarcopenia, affects a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). However, its influence on post-TAVR recovery and 1-year health-related quality of life (HR-QOL) remains unknown. We examined the relationship between skeletal muscle index (SMI), post-TAVR length of hospital stay (LOS), and 1-year QOL.
METHODS
The study sample consisted of 300 consecutive patients undergoing TAVR from 2012 to 2018 who had pre-TAVR computed tomographic scans suitable for analysis of body composition. Skeletal muscle mass was quantified as cm
RESULTS
Sarcopenia was present in most (59%) patients and associated with older age (82 vs 76 years; P < .001) and lower body mass index (27 vs 33 kg/m
CONCLUSIONS
Sarcopenia is prevalent in TAVR patients. Higher SMI is associated with shorter LOS and better 1-year HR-QOL. To achieve optimal TAVR benefits, further study into how body composition influences post-TAVR recovery and durable improvement in QOL is warranted.
Identifiants
pubmed: 32416332
pii: S0002-8703(20)30105-8
doi: 10.1016/j.ahj.2020.03.021
pmc: PMC8132132
mid: NIHMS1695804
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-181Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL153771
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI120834
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021334
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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