Bariatric Surgery is feasible in patients with Ehlers-Danlos Syndrome.


Journal

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
ISSN: 1878-7533
Titre abrégé: Surg Obes Relat Dis
Pays: United States
ID NLM: 101233161

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 30 01 2020
revised: 13 03 2020
accepted: 26 03 2020
pubmed: 18 5 2020
medline: 28 4 2021
entrez: 18 5 2020
Statut: ppublish

Résumé

Ehlers-Danlos syndrome (EDS) is a heterogeneous disease affecting connective tissues. EDS patients have a high susceptibility for developing anastomotic leak after visceral surgery. Although patients with EDS can also develop severe obesity and might be referred to bariatric surgery, there is just 1 case report in the literature regarding the outcomes of bariatric surgery in this specific context. To report the cases of patients with EDS and severe obesity that underwent bariatric surgery. Five French hospitals (University Hospital of Nantes, APHP Pitié Salpêtrière Hospital, APHP Bichat Hospital, Clinique St Gregoire Rennes, and Clinique Mutualiste de l'Estuaire St Nazaire). We report the cases of 7 patients with EDS and severe obesity who underwent surgery. All patients showed classical postoperative course except for 1 case of excessive bleeding. There was no increased pain, leak, and solid parietal healing was achieved in all patients at 1 month postoperatively. The percent excess weight loss at 1 and 6 months were 13.9 ± 3.8% and 45.3 ± 16%, respectively. Our study shows that bariatric surgery is a relevant and apparently safe surgical option to consider in severely obese patients with EDS.

Sections du résumé

BACKGROUND BACKGROUND
Ehlers-Danlos syndrome (EDS) is a heterogeneous disease affecting connective tissues. EDS patients have a high susceptibility for developing anastomotic leak after visceral surgery. Although patients with EDS can also develop severe obesity and might be referred to bariatric surgery, there is just 1 case report in the literature regarding the outcomes of bariatric surgery in this specific context.
OBJECTIVE OBJECTIVE
To report the cases of patients with EDS and severe obesity that underwent bariatric surgery.
SETTING METHODS
Five French hospitals (University Hospital of Nantes, APHP Pitié Salpêtrière Hospital, APHP Bichat Hospital, Clinique St Gregoire Rennes, and Clinique Mutualiste de l'Estuaire St Nazaire).
METHODS METHODS
We report the cases of 7 patients with EDS and severe obesity who underwent surgery.
RESULTS RESULTS
All patients showed classical postoperative course except for 1 case of excessive bleeding. There was no increased pain, leak, and solid parietal healing was achieved in all patients at 1 month postoperatively. The percent excess weight loss at 1 and 6 months were 13.9 ± 3.8% and 45.3 ± 16%, respectively.
CONCLUSION CONCLUSIONS
Our study shows that bariatric surgery is a relevant and apparently safe surgical option to consider in severely obese patients with EDS.

Identifiants

pubmed: 32417148
pii: S1550-7289(20)30181-7
doi: 10.1016/j.soard.2020.03.033
pii:
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1328-1331

Informations de copyright

Copyright © 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

Auteurs

Lucas Verdure (L)

Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Centre Hospitalo-universitaire de Nantes, Hôtel-Dieu, Nantes, France.

Laurent Genser (L)

Service de Chirurgie Digestive, Hépato-bilio-pancréatique et Transplantation Hépatique, Groupe Hospitalier Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Institut hospitalo-universitaire ICAN, Paris, France.

Lionel Rebibo (L)

Service de Chirurgie Générale, Digestive, Bariatrique et Oesogastrique, Assistance Publique-Hôpitaux de Paris-Hôpital Bichat - Claude-Bernard, Paris, France.

Céline Brient (C)

Chirurgie Générale et Digestive, Clinique Mutualiste de St Nazaire, Cité Sanitaire, Saint Nazaire, France.

Adrien Sterkers (A)

Department of Digestive, Hepatobiliary Surgery, Centre Hospitalier Privé Saint Grégoire, Saint Gregoire, France.

David Jacobi (D)

L'Institut du Thorax, Department of Endocrinology, Centre Hospitalier Universitaire Nantes, Nantes, France.

Louise Lallemand (L)

Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Centre Hospitalo-universitaire de Nantes, Hôtel-Dieu, Nantes, France.

Eric Mirallie (E)

Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Centre Hospitalo-universitaire de Nantes, Hôtel-Dieu, Nantes, France.

Judith Aron-Wisnewsky (J)

Sorbonne Université, INSERM, Nutrition and Obesities: Systemic Approaches (NutriOMics) Research Unit, Paris, France; Assistance Publique des Hôpitaux de Paris, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.

Claire Blanchard (C)

Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Centre Hospitalo-universitaire de Nantes, Hôtel-Dieu, Nantes, France; L'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France. Electronic address: Claire.blanchard@chu-nantes.fr.

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