The effects of morphine withdrawal and conditioned withdrawal on memory consolidation and c-Fos expression in the central amygdala.
Animals
Central Amygdaloid Nucleus
/ diagnostic imaging
Memory Consolidation
/ drug effects
Morphine
/ pharmacology
Naloxone
/ pharmacology
Narcotic Antagonists
/ pharmacology
Narcotics
/ pharmacology
Proto-Oncogene Proteins c-fos
/ drug effects
Rats
Rats, Sprague-Dawley
Substance Withdrawal Syndrome
/ pathology
Weight Loss
central nucleus of the amygdala
conditioned withdrawal
memory consolidation
morphine
object recognition
withdrawal
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
18
11
2019
revised:
31
01
2020
accepted:
05
04
2020
pubmed:
18
5
2020
medline:
19
1
2022
entrez:
18
5
2020
Statut:
ppublish
Résumé
The current study tested the hypothesis that drug withdrawal contributes to the addiction cycle in part because of an action on memory consolidation. Hence, four experiments in male Sprague-Dawley rats compared the effects of precipitated morphine withdrawal and conditioned morphine withdrawal on the consolidation of object memory and on activation of c-Fos in the central nucleus of the amygdala (CeA). It was found that immediate, but not 6 h delayed, post sample administration of 3 mg/kg of naltrexone significantly enhanced object memory in rats maintained, or previously maintained, on 10 mg/kg/day of morphine via osmotic minipumps. To establish whether conditioned withdrawal could also alter object memory, a contextual conditioning procedure was employed whereby morphine-maintained (10 mg/kg/day) animals received naltrexone (3 mg/kg) in a distinctive context (CS+) and vehicle in a separate context (CS-) for 10 days. During conditioning in the CS+, naltrexone suppressed locomotor activity, caused a rapid body weight loss and increased frequency of wet dog shakes. Interestingly, confinement to this CS+ immediately, but not 6 h, after the sample phase, also enhanced object memory. Finally, posttraining naltrexone and exposure to the CS+ both induced significant expression of c-Fos in the CeA. Therefore, this study reports for the first time that both acute precipitated withdrawal and conditioned withdrawal can facilitate memory consolidation, possibly through a common neural pathway that involves the central amygdala.
Substances chimiques
Narcotic Antagonists
0
Narcotics
0
Proto-Oncogene Proteins c-fos
0
Naloxone
36B82AMQ7N
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12909Informations de copyright
© 2020 Society for the Study of Addiction.
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