Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents.
Chalcone
MIC
Staphylococcus aureus
antibacterial activity
piperazine
sulphonamide.
Journal
Current organic synthesis
ISSN: 1570-1794
Titre abrégé: Curr Org Synth
Pays: United Arab Emirates
ID NLM: 101208457
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
10
2019
revised:
22
11
2019
accepted:
07
12
2019
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
18
5
2021
Statut:
ppublish
Résumé
Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections. To study the antibacterial activity of piperazine substituted chalcone sulphonamides. A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated. The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL. Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.
Sections du résumé
BACKGROUND
Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections.
OBJECTIVE
To study the antibacterial activity of piperazine substituted chalcone sulphonamides.
MATERIALS AND METHODS
A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated.
RESULTS
The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.
CONCLUSION
Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.
Identifiants
pubmed: 32418516
pii: COS-EPUB-103272
doi: 10.2174/1570179417666191227115207
doi:
Substances chimiques
Anti-Bacterial Agents
0
Chalcones
0
Piperazines
0
Sulfonamides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136-143Informations de copyright
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