A systematic review and meta-analysis of higher expression of folate receptor alpha (FOLR1) predicts poor cancer prognosis.
FOLR1
cancer
clinicopathological parameters
meta-analysis
prognosis
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Titre abrégé: Biomarkers
Pays: England
ID NLM: 9606000
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
pubmed:
19
5
2020
medline:
15
4
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
Folate receptor alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is a well characterized folate transporter. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. Twelve studies involving 4471 patients were included in this meta-analysis. The pooled analysis indicated that high FOLR1 significantly predicted poor overall survival (OS) (pooled hazard ratio (HR) = 0.78, 95% confidence interval (CI) = 0.64-0.94,
Identifiants
pubmed: 32421366
doi: 10.1080/1354750X.2020.1771420
doi:
Substances chimiques
Biomarkers, Tumor
0
FOLR1 protein, human
0
Folate Receptor 1
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM