Structural features of pectic polysaccharides from stems of two species of Radix Codonopsis and their antioxidant activities.

Animals Antioxidants / chemistry Cell Line Codonopsis / chemistry Magnetic Resonance Spectroscopy Molecular Structure Molecular Weight Monosaccharides Plant Stems / chemistry Polysaccharides / chemistry Structure-Activity Relationship Swine
Antioxidant activity Codonopsis stem polysaccharides Structural characterization

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
15 Sep 2020
Historique:
received: 01 04 2020
revised: 26 04 2020
accepted: 13 05 2020
pubmed: 19 5 2020
medline: 19 3 2021
entrez: 19 5 2020
Statut: ppublish

Résumé

In this study, two pectic polysaccharides from stems of Codonopsis pilosula (CPSP-1) and C. tangshen (CTSP-1) were obtained by ion exchange chromatography and gel filtration. The molecular weight of CPSP-1 and CTSP-1 were 13.1 and 23.0 kDa, respectively. The results of structure elucidation indicated that both CPSP-1 and CTSP-1 are pectic polysaccharides with long homogalacturonan regions (HG) (some of galacturonic acid units were methyl esterified) and rhamnogalacturonan I (RG-I) regions. Side chains for CTSP-1 are both arabinogalactan type I (AG-I) and type II (AG-II), while CPSP-1 only has AG-II. The biological test demonstrated that CPSP-1 and CTSP-1 displayed an antioxidant property through mediating the intestinal cellular antioxidant defense system, which could protect cultured intestinal cells from oxidative stress induced oxidative damages and cell viability suppression. CPSP-1 and CTSP-I showed different bioactivities and mechanisms, which may be due to the difference in their structures.

Identifiants

DOI: 10.1016/j.ijbiomac.2020.05.083 PMID: 32422266
pubmed: 32422266
pii: S0141-8130(20)33238-4
doi: 10.1016/j.ijbiomac.2020.05.083
pii:
doi:

Substances chimiques

Antioxidants 0
Monosaccharides 0
Polysaccharides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

704-713

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Auteurs

Yuan-Feng Zou (YF)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China. Electronic address: yuanfengzou@sicau.edu.cn.

Yan-Yun Zhang (YY)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Berit Smestad Paulsen (BS)

Department of Pharmacy, Section Pharmaceutical Chemistry, Area Pharmacognosy, University of Oslo, P.O. Box 1068, Blindern, 0316 Oslo, Norway.

Frode Rise (F)

Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, 0315 Oslo, Norway.

Zheng-Li Chen (ZL)

Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Ren-Yong Jia (RY)

Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Li-Xia Li (LX)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Xu Song (X)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Bin Feng (B)

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, PR China.

Hua-Qiao Tang (HQ)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.

Chao Huang (C)

Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Department of Pharmacy, Section Pharmaceutical Chemistry, Area Pharmacognosy, University of Oslo, P.O. Box 1068, Blindern, 0316 Oslo, Norway.

Zhong-Qiong Yin (ZQ)

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China. Electronic address: yinzhongq@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural features of pectic polysaccharides...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Structural features of pectic polysaccharides...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structural features of pectic polysaccharides...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Campanulaceae › Codonopsis › Structural features of pectic polysaccharides...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Structural features of pectic polysaccharides...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structural features of pectic polysaccharides...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › Structural features of pectic polysaccharides...
questionsmedicales.fr › Glucides › Sucres › Oses › Structural features of pectic polysaccharides...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › Structural features of pectic polysaccharides...
questionsmedicales.fr › Glucides › Polyosides › Structural features of pectic polysaccharides...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structural features of pectic polysaccharides...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Structural features of pectic polysaccharides...