HDVdb: A Comprehensive Hepatitis D Virus Database.
Webserver
database
genotyping
hepatitis delta virus
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
received:
26
03
2020
revised:
10
05
2020
accepted:
11
05
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
18
2
2021
Statut:
epublish
Résumé
Hepatitis D virus (HDV) causes the most severe form of viral hepatitis, which may rapidly progress to liver cirrhosis and hepatocellular carcinoma (HCC). It has been estimated that 15-20 million people worldwide are suffering from the chronic HDV infection. Currently, no effective therapies are available to treat acute or chronic HDV infection. The remarkable sequence variability of the HDV genome, particularly within the hypervariable region has resulted in the provisional classification of eight major genotypes and various subtypes. We have developed a specialized database, HDVdb (http://hdvdb.bio.wzw.tum.de/), which contains a collection of partial and complete HDV genomic sequences obtained from the GenBank and from our own patient cohort. HDVdb enables the researchers to investigate the genetic variability of all available HDV sequences, correlation of genotypes to epidemiology and pathogenesis. Additionally, it will contribute in understanding the drug resistant mutations and develop effective vaccines against HDV infection. The database can be accessed through a web interface that allows for static and dynamic queries and offers integrated generic and specialized sequence analysis tools, such as annotation, genotyping, primer prediction, and phylogenetic analyses.
Identifiants
pubmed: 32422927
pii: v12050538
doi: 10.3390/v12050538
pmc: PMC7290977
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Infect Dis (Lond). 2019 Aug;51(8):622-624
pubmed: 31165648
Nucleic Acids Res. 2008 Jan;36(Database issue):D512-6
pubmed: 18025038
Nat Commun. 2019 May 8;10(1):2098
pubmed: 31068585
mBio. 2019 Apr 2;10(2):
pubmed: 30940697
Emerg Infect Dis. 2006 Sep;12(9):1447-50
pubmed: 17073101
Virol J. 2015 Oct 24;12:172
pubmed: 26497287
J Clin Microbiol. 2008 Feb;46(2):754-6
pubmed: 18077651
Gastroenterology. 2019 May;156(6):1820-1833
pubmed: 30768983
Rev Soc Bras Med Trop. 2019 Jan 24;52:e20180289
pubmed: 30698197
Viruses. 2017 Jul 04;9(7):
pubmed: 28677645
J Virol. 2018 Jan 30;92(4):
pubmed: 29212929
Nucleic Acids Res. 2015 Jan;43(Database issue):D30-5
pubmed: 25414350
Hepatology. 2017 Dec;66(6):1826-1841
pubmed: 28992360
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):877-889
pubmed: 28964701
J Med Virol. 2001 Jul;64(3):356-9
pubmed: 11424126
Viruses. 2018 Dec 17;10(12):
pubmed: 30562970
Annu Rev Biochem. 1995;64:259-86
pubmed: 7574482
Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
Virus Res. 2016 Sep 15;224:6-11
pubmed: 27515509
AIDS Rev. 2003 Jan-Mar;5(1):52-61
pubmed: 12875108
Lancet Infect Dis. 2019 Mar;19(3):275-286
pubmed: 30833068
Gut. 2019 Mar;68(3):512-521
pubmed: 30228220
N Engl J Med. 2011 Jan 27;364(4):322-31
pubmed: 21268724
Virus Evol. 2019 Jul 15;5(2):vez021
pubmed: 31321078
Lancet. 1982 Oct 30;2(8305):945-7
pubmed: 6127458
J Virol. 2004 Mar;78(5):2537-44
pubmed: 14963156
J Gen Virol. 2009 Nov;90(Pt 11):2638-2643
pubmed: 19605587
J Gen Virol. 2001 Nov;82(Pt 11):2709-2718
pubmed: 11602783
Virus Res. 2011 Sep;160(1-2):333-9
pubmed: 21798297
J Virol. 1988 Feb;62(2):594-9
pubmed: 2447291
J Viral Hepat. 2019 Jul;26(7):900-910
pubmed: 30801877
J Med Virol. 1999 Aug;58(4):366-72
pubmed: 10421403
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
Nucleic Acids Res. 2013 Jan;41(Database issue):D566-70
pubmed: 23125365
J Hepatol. 2016 Sep;65(3):490-8
pubmed: 27132170
Hepatology. 1997 Mar;25(3):728-34
pubmed: 9049226
Gastroenterology. 2019 May;156(6):1805-1819.e9
pubmed: 30664876
Adv Bioinformatics. 2010;:323654
pubmed: 20204073
J Hepatol. 2018 Jul;69(1):25-35
pubmed: 29524530
Curr Top Microbiol Immunol. 2006;307:67-89
pubmed: 16903221
Gastroenterology. 2006 May;130(6):1625-35
pubmed: 16697726
Curr Gastroenterol Rep. 2014 Jan;16(1):365
pubmed: 24293018
Hepatology. 2014 Jul;60(1):87-97
pubmed: 24585488
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9016-20
pubmed: 8415646
J Med Virol. 1996 Jun;49(2):145-54
pubmed: 8991938
J Mol Biol. 1990 Oct 5;215(3):403-10
pubmed: 2231712
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7
pubmed: 15034147
Syst Biol. 2010 May;59(3):307-21
pubmed: 20525638