Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity.
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
30 06 2020
30 06 2020
Historique:
received:
31
03
2020
accepted:
03
04
2020
pubmed:
20
5
2020
medline:
20
1
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
In mouse, there are four stearoyl-CoA desaturase isoforms (SCD1-4) that catalyze the synthesis of monounsaturated fatty acids. Previously, we have shown that mice harboring a whole body deletion of the SCD1 isoform (SCD1KO) are protected from diet and genetically induced adiposity. Here, we report that global deletion of the SCD2 isoform (SCD2KO) provides a similar protective effect against the onset of both high-fat diet (HFD) and high-carbohydrate diet (HCD) induced adiposity. After 10 weeks of HFD feeding or 6 weeks of HCD feeding, SCD2KO mice failed to gain weight and had decreased fat mass. On HFD, SCD2KO mice remained glucose and insulin tolerant. Lastly, the markers for energy expenditure, UCP1 and PGC-1α, were increased in the brown adipose tissue of HFD fed SCD2KO mice.
Identifiants
pubmed: 32423819
pii: S0006-291X(20)30803-2
doi: 10.1016/j.bbrc.2020.04.077
pmc: PMC7310674
mid: NIHMS1595191
pii:
doi:
Substances chimiques
Insulin
0
Scd2 protein, mouse
EC 1.14.19.1
Stearoyl-CoA Desaturase
EC 1.14.19.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
589-595Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK062388
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118093
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007215
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflicts of interest to declare.
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