Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.
Analgesics
/ pharmacology
Animals
Antioxidants
/ pharmacology
Cell Line, Tumor
Humans
Hyperalgesia
/ drug therapy
Male
Metalloporphyrins
/ pharmacology
Oxidative Stress
/ drug effects
Pain Threshold
/ drug effects
Protein Carbonylation
Rats, Sprague-Dawley
Reactive Oxygen Species
/ metabolism
Resveratrol
/ pharmacology
Signal Transduction
Sirtuins
/ genetics
Spinal Cord
/ drug effects
Superoxide Dismutase
/ metabolism
2,4 dinitrophenylhydrazine (DNPH) (Pubchem CID: 3772977)
4-hydroxynonenal (4-HNE) (Pubchem CID: 5283344)
Carrageenan (Pubchem CID: 91972149)
Inflammatory hyperalgesia
Mitochondrial dysfunction
Mn (III) tetrakis (4-benzoic) porfirin (MnTBAP) (Pubchem CID: 16760566)
Natural antioxidants
Oxidative stress
Resveratrol (Pubchem CID: 445154)
SIRT3
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
04
11
2019
revised:
18
04
2020
accepted:
19
04
2020
pubmed:
20
5
2020
medline:
1
6
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
Oxidative stress induced post-translational protein modifications are associated with the development of inflammatory hypersensitivities. At least 90% of cellular reactive oxygen species (ROS) are produced in the mitochondria, where the mitochondrial antioxidant, manganese superoxide dismutase (MnSOD), is located. MnSOD's ability to reduce ROS is enhanced by the mitochondrial NAD
Identifiants
pubmed: 32423865
pii: S1043-6618(20)31159-2
doi: 10.1016/j.phrs.2020.104851
pii:
doi:
Substances chimiques
Analgesics
0
Antioxidants
0
Metalloporphyrins
0
Reactive Oxygen Species
0
SIRT3 protein, rat
0
manganese(III)-tetrakis(4-benzoic acid)porphyrin
0
Superoxide Dismutase
EC 1.15.1.1
Sirtuins
EC 3.5.1.-
Resveratrol
Q369O8926L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104851Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors declare no conflict of interest.