COVID-19 as an Acute Inflammatory Disease.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
14
04
2020
accepted:
06
05
2020
pubmed:
20
5
2020
medline:
27
6
2020
entrez:
20
5
2020
Statut:
ppublish
Résumé
The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented global crisis for the infrastructure sectors, including economic, political, healthcare, education, and research systems. Although over 90% of infected individuals are asymptomatic or manifest noncritical symptoms and will recover from the infection, those individuals presenting with critical symptoms are in urgent need of effective treatment options. Emerging data related to mechanism of severity and potential therapies for patients presenting with severe symptoms are scattered and therefore require a comprehensive analysis to focus research on developing effective therapeutics. A critical literature review suggests that the severity of SARS-CoV-2 infection is associated with dysregulation of inflammatory immune responses, which in turn inhibits the development of protective immunity to the infection. Therefore, the use of therapeutics that modulate inflammation without compromising the adaptive immune response could be the most effective therapeutic strategy.
Identifiants
pubmed: 32423917
pii: jimmunol.2000413
doi: 10.4049/jimmunol.2000413
pmc: PMC7333792
mid: NIHMS1598877
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-19Subventions
Organisme : NCI NIH HHS
ID : P30 CA016059
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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