Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis.
Empirical antibiotics
Meta-analysis
Necrotizing enterocolitis
Preterm infants
Risk factors
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
16
01
2020
accepted:
08
05
2020
revised:
29
04
2020
pubmed:
20
5
2020
medline:
24
3
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
Whether the prophylactic use of antibiotics increase the risk of necrotizing enterocolitis (NEC) remains controversial. This review aims to investigate initial empirical antibiotic therapy (IEAT) and is associated with the risk of NEC. PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched through March 1, 2020. All studies on the impacts of antibiotic exposure on NEC development were included. Thirteen studies including 7901 participants were selected. Two reviewers independently examined the extracted data and assessed the quality of the included studies. Random-effects model was used to pool the effect estimates. We found that IEAT (≥ 5 days) was associated with an increased risk of NEC in adjusted (Odds risk [OR] 1.51, 95% confidence interval [CI] 1.22-1.87) and unadjusted (OR 2.35, 95% CI 1.54-3.57) analyses. Sensitivity analysis also supported these findings.Conclusion: The evidence suggests an association between IEAT (≥ 5 days) and the risk of NEC. Further studies are needed to address whether the association with IEAT is causal.What is Known:•Necrotizing enterocolitis (NEC) is acute inflammatory necrosis of the intestinal tractin the newborn infant.•Some observational studies have associated initial empirical antibiotics with an increased risk of subsequent NEC.What is New:•Initial empirical antibiotic therapy (IEAT) (≥ 5 days) appear to increase the risk of NEC.
Identifiants
pubmed: 32424744
doi: 10.1007/s00431-020-03679-4
pii: 10.1007/s00431-020-03679-4
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1047-1056Subventions
Organisme : the National Science Foundation of China
ID : 81630038
Organisme : the National Science Foundation of China
ID : 81971433
Organisme : the National Science Foundation of China
ID : 81971428
Organisme : the National Science Foundation of China
ID : 81771634
Organisme : the National Key R&D Program of China
ID : 2017YFA0104200
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