Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.

Acetylcholinesterase / metabolism Adenosine Triphosphate / metabolism Animals Anti-Inflammatory Agents / pharmacology Apoptosis / drug effects Benzhydryl Compounds / toxicity Cyclic GMP / metabolism Cyclic GMP-Dependent Protein Kinases / metabolism Erectile Dysfunction / blood Flavanones / pharmacology Hypertension / blood Male Malondialdehyde / blood Monoamine Oxidase / metabolism NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide Synthase / metabolism Penis / drug effects Peptidyl-Dipeptidase A / blood Phenols / toxicity Rats, Wistar
Apoptosis Environmental toxicant Erectile dysfunction Hypertension Inflammation Naringin Rat model

Journal

Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591

Informations de publication

Date de publication:
08 2020
Historique:
received: 10 01 2020
revised: 11 05 2020
accepted: 13 05 2020
pubmed: 20 5 2020
medline: 29 4 2021
entrez: 20 5 2020
Statut: ppublish

Résumé

This study investigated the effect of naringin (NRG) on extracellular metabolism of ATP through the NOS/cGMP/PKG signaling pathway induced by Nω-nitro-L-arginine methyl ester hydrochloride (

Identifiants

DOI: 10.1016/j.reprotox.2020.05.007 PMID: 32428650
pubmed: 32428650
pii: S0890-6238(20)30135-0
doi: 10.1016/j.reprotox.2020.05.007
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Benzhydryl Compounds 0
Flavanones 0
Phenols 0
Malondialdehyde 4Y8F71G49Q
Adenosine Triphosphate 8L70Q75FXE
Nitric Oxide Synthase EC 1.14.13.39
Monoamine Oxidase EC 1.4.3.4
Cyclic GMP-Dependent Protein Kinases EC 2.7.11.12
Acetylcholinesterase EC 3.1.1.7
Peptidyl-Dipeptidase A EC 3.4.15.1
Cyclic GMP H2D2X058MU
bisphenol A MLT3645I99
naringin N7TD9J649B
NG-Nitroarginine Methyl Ester V55S2QJN2X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

123-136

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors have no conflicts of interest to declare

Auteurs

J K Akintunde (JK)

Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria. Electronic address: akintundejacob@yahoo.com.

T E Akintola (TE)

Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

F H Aliu (FH)

Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

M O Fajoye (MO)

Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

S O Adimchi (SO)

Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Eucaryotes › Animaux › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › GMP cyclique › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic GMP-Dependent Protein Kinases › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Troubles mentaux › Dysfonctionnements sexuels psychogènes › Dysfonctionnement érectile › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavanones › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Malonaldéhyde › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés diaminés › L-NAME › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de l'homme › Pénis › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Naringin regulates erectile dysfunction by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Naringin regulates erectile dysfunction by...