Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in
3-Hydroxybutyric Acid
/ pharmacology
Aging
/ drug effects
Animals
Centrosome
/ metabolism
DNA Damage
Drosophila melanogaster
/ cytology
Heterochromatin
/ metabolism
Intestines
/ cytology
Ketones
/ metabolism
Metabolome
/ drug effects
Oxidative Stress
/ drug effects
Stem Cell Niche
/ drug effects
Stem Cells
/ cytology
DNA damage
Drosophila midgut
Niche
aging
centrosome amplification
heterochromatin stability
intestinal stem cell
β-hydroxybutyrate
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
06
04
2020
revised:
01
05
2020
accepted:
11
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the
Identifiants
pubmed: 32429095
pii: ijms21103497
doi: 10.3390/ijms21103497
pmc: PMC7278929
pii:
doi:
Substances chimiques
Heterochromatin
0
Ketones
0
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Genes Dev. 2009 Oct 1;23(19):2333-44
pubmed: 19797770
Cell Stem Cell. 2008 Oct 9;3(4):442-55
pubmed: 18940735
Dev Biol. 2015 Mar 15;399(2):189-203
pubmed: 25553980
Aging (Albany NY). 2018 Mar 7;10(3):322-338
pubmed: 29514136
Fly (Austin). 2008 Nov-Dec;2(6):310-2
pubmed: 19077540
IUBMB Life. 2017 May;69(5):305-314
pubmed: 28371201
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18702-7
pubmed: 22049341
Curr Stem Cell Rep. 2017 Mar;3(1):1-8
pubmed: 28966904
BMC Biol. 2010 Dec 22;8:152
pubmed: 21176204
Annu Rev Nutr. 2017 Aug 21;37:51-76
pubmed: 28826372
Cell Mol Life Sci. 2016 Sep;73(17):3337-49
pubmed: 27137186
Mol Cell. 2018 Sep 20;71(6):1064-1078.e5
pubmed: 30197300
Nature. 2001 Mar 1;410(6824):116-20
pubmed: 11242053
Nature. 2001 Nov 1;414(6859):98-104
pubmed: 11689954
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15998-6003
pubmed: 15520384
Cell Death Differ. 2017 Mar;24(3):458-468
pubmed: 27935584
Science. 2013 Jan 11;339(6116):211-4
pubmed: 23223453
J Physiol. 1980 Apr;301:79-90
pubmed: 6997456
Dev Cell. 2013 Jan 28;24(2):133-43
pubmed: 23369712
Cell Cycle. 2006 Nov;5(22):2671-5
pubmed: 17106266
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
Nature. 2008 Oct 23;455(7216):1119-23
pubmed: 18806781
Cancer Metab. 2017 Feb 28;5:4
pubmed: 28261475
Development. 2010 Dec;137(24):4147-58
pubmed: 21068063
Front Nutr. 2019 May 14;6:63
pubmed: 31139630
Front Cell Infect Microbiol. 2014 Apr 24;4:49
pubmed: 24795868
Mol Cell. 1999 Mar;3(3):389-95
pubmed: 10198641
Exp Gerontol. 2012 May;47(5):401-5
pubmed: 22387531
Nat Rev Cancer. 2002 Nov;2(11):815-25
pubmed: 12415252
Elife. 2014 Mar 11;3:e01857
pubmed: 24618900
Development. 2011 Mar;138(6):1045-55
pubmed: 21307097
Nature. 2006 Jun 29;441(7097):1080-6
pubmed: 16810243
Aging (Albany NY). 2009 May 21;1(7):637-51
pubmed: 20157545
Exp Cell Res. 2011 Nov 15;317(19):2780-8
pubmed: 21856297
J Cell Sci. 2012 Dec 15;125(Pt 24):5944-9
pubmed: 23038775
Cell. 2009 Jun 26;137(7):1343-55
pubmed: 19563763
Mech Ageing Dev. 2015 Jul;149:8-18
pubmed: 25988874
Cell. 2011 Oct 28;147(3):603-14
pubmed: 22036568
Curr Biol. 2013 Feb 4;23(3):R110-2
pubmed: 23391384
Science. 2007 Feb 16;315(5814):988-92
pubmed: 17303754
Genetics. 1993 Jul;134(3):781-8
pubmed: 8349109
Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19
pubmed: 14769489
Aging Cell. 2008 Jun;7(3):318-34
pubmed: 18284659
Cell Host Microbe. 2009 Feb 19;5(2):200-11
pubmed: 19218090
J Biol Chem. 2012 Aug 10;287(33):27359-70
pubmed: 22722927
Cell Stem Cell. 2011 Jan 7;8(1):84-95
pubmed: 21167805
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21064-9
pubmed: 21078993
EMBO J. 2012 Oct 3;31(19):3901-17
pubmed: 22948071
PLoS Genet. 2010 Oct 14;6(10):e1001159
pubmed: 20976250
Trends Pharmacol Sci. 2010 Feb;31(2):89-98
pubmed: 20097433
Mech Ageing Dev. 2018 Jul;173:50-60
pubmed: 29625135
Dev Biol. 2010 Feb 1;338(1):28-37
pubmed: 19896937
Nature. 2006 Jan 26;439(7075):470-4
pubmed: 16340960
Development. 2010 Dec;137(24):4135-45
pubmed: 21098564
J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1424-1434
pubmed: 27535968
Development. 2009 Feb;136(3):483-93
pubmed: 19141677
Nature. 2006 Jan 26;439(7075):475-9
pubmed: 16340959
J Mol Med (Berl). 2020 Jan;98(1):25-37
pubmed: 31713638
Genes Dev. 2009 Oct 1;23(19):2260-5
pubmed: 19797765
Aging (Albany NY). 2014 Aug;6(8):621-44
pubmed: 25127866
Dis Model Mech. 2011 Jan;4(1):21-30
pubmed: 21183483
Radiat Res. 2014 Apr;181(4):376-86
pubmed: 24701963
Mech Ageing Dev. 2013 Sep;134(9):381-90
pubmed: 23891756
Biochem Biophys Res Commun. 2014 Jul 25;450(2):961-5
pubmed: 24971546