Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease.

Amino Acid Sequence Animals Cell Adhesion Molecules, Neuronal / chemistry Disease Health Humans Hyaluronan Receptors / chemistry Ligands Neoplasms / pathology Protein Domains
HARE MAPK Stabilin-2 clearance hyaluronan ligand receptor signaling

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
15 May 2020
Historique:
received: 21 04 2020
revised: 08 05 2020
accepted: 14 05 2020
entrez: 21 5 2020
pubmed: 21 5 2020
medline: 11 2 2021
Statut: epublish

Résumé

Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.

Identifiants

DOI: 10.3390/ijms21103504 PMID: 32429122 PMC: PMC7279005
pubmed: 32429122
pii: ijms21103504
doi: 10.3390/ijms21103504
pmc: PMC7279005
pii:
doi:

Substances chimiques

Cell Adhesion Molecules, Neuronal 0
Hyaluronan Receptors 0
Ligands 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL130864
Pays : United States
Organisme : NIH HHS
ID : HL130864
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Edward N Harris (EN)

Dept of Biochemistry, University of Nebraska, 1901 Vine St., Lincoln, NE 68588, USA.

Erika Baker (E)

Dept of Biochemistry, University of Nebraska, 1901 Vine St., Lincoln, NE 68588, USA.

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Classifications MeSH

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