Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family.
Amaryllidaceae
/ chemistry
Amaryllidaceae Alkaloids
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Antiprotozoal Agents
/ chemistry
Cell Line, Tumor
Cholinesterase Inhibitors
/ chemistry
Galantamine
/ chemistry
Heterocyclic Compounds, 4 or More Rings
/ chemistry
Humans
Inhibitory Concentration 50
Isoquinolines
/ chemistry
Nootropic Agents
/ chemistry
Phenanthridines
/ chemistry
Plant Extracts
/ chemistry
Secondary Metabolism
Amaryllidaceae
alkaloids
biological activity
derivatives
montanine
montanine-type
pancracine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 May 2020
16 May 2020
Historique:
received:
24
04
2020
revised:
11
05
2020
accepted:
12
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Plants of the Amaryllidaceae family are promising therapeutic tools for human diseases and have been used as alternative medicines. The specific secondary metabolites of this plant family, called Amaryllidaceae alkaloids (AA), have attracted considerable attention due to their interesting pharmacological activities. One of them, galantamine, is already used in the therapy of Alzheimer's disease as a long acting, selective, reversible inhibitor of acetylcholinesterase. One group of AA is the montanine-type, such as montanine, pancracine and others, which share a 5,11-methanomorphanthridine core. So far, only 14 montanine-type alkaloids have been isolated. Compared with other structural-types of AA, montanine-type alkaloids are predominantly present in plants in low concentrations, but some of them display promising biological properties, especially in vitro cytotoxic activity against different cancerous cell lines. The present review aims to summarize comprehensively the research that has been published on the Amaryllidaceae alkaloids of montanine-type.
Identifiants
pubmed: 32429491
pii: molecules25102337
doi: 10.3390/molecules25102337
pmc: PMC7288066
pii:
doi:
Substances chimiques
Amaryllidaceae Alkaloids
0
Antineoplastic Agents, Phytogenic
0
Antiprotozoal Agents
0
Cholinesterase Inhibitors
0
Heterocyclic Compounds, 4 or More Rings
0
Isoquinolines
0
Nootropic Agents
0
Phenanthridines
0
Plant Extracts
0
montanine
0
pancracine
0
Galantamine
0D3Q044KCA
hemanthamine
466-75-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Univerzita Karlova v Praze
ID : SVV UK 260 548; Progres/UK Q40-01 and Q42
Organisme : European Union
ID : CZ.02.1.01/0.0/0.0/18_069/0010046
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