Hidden Carcinoma: Pitfalls in the Diagnosis of Lymphoepithelioma-Like Cholangiocarcinoma.
Antineoplastic Agents
/ therapeutic use
Bile Duct Neoplasms
/ diagnosis
Bile Ducts, Intrahepatic
/ diagnostic imaging
Biopsy
Cholangiocarcinoma
/ diagnosis
Cholangiopancreatography, Magnetic Resonance
Diagnostic Errors
Epstein-Barr Virus Infections
/ diagnosis
Fatal Outcome
Frozen Sections
Hepatectomy
Herpesvirus 4, Human
/ genetics
Hodgkin Disease
/ diagnosis
Humans
Middle Aged
Pseudolymphoma
/ diagnosis
RNA, Viral
/ isolation & purification
Young Adult
EBER
Epstein-Bar virus
lymphoepithelioma-like cholangiocarcinoma
Journal
International journal of surgical pathology
ISSN: 1940-2465
Titre abrégé: Int J Surg Pathol
Pays: United States
ID NLM: 9314927
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
21
5
2020
medline:
22
6
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Lymphoepithelioma-like intrahepatic cholangiocarcinoma is a rare variant of cholangiocarcinoma that is associated with the Epstein-Barr virus. The intimate relationship between the malignant epithelial cells and the numerous lymphoid cells can make the diagnosis challenging on limited tissue samples. We present 2 cases in which the presence of a dense hematolymphoid infiltrate served to mask the diagnosis of carcinoma on initial frozen section and biopsy review, respectively. We bring awareness to this potential diagnostic pitfall and offer morphologic and immunohistochemical clues that may aid in recognition of this unusual and sometimes perplexing carcinoma.
Identifiants
pubmed: 32429781
doi: 10.1177/1066896920921560
doi:
Substances chimiques
Antineoplastic Agents
0
RNA, Viral
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM