Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non-Small Cell Lung Cancer.

Biomarkers, Tumor / blood Carcinoma, Non-Small-Cell Lung / blood Cysteine Dioxygenase / blood DNA Methylation / genetics Early Detection of Cancer Female Homeodomain Proteins / blood Humans Male Middle Aged Promoter Regions, Genetic / genetics SOXF Transcription Factors / blood Tachykinins / blood

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 08 2020
Historique:
received: 07 10 2019
revised: 16 01 2020
accepted: 14 05 2020
pubmed: 21 5 2020
medline: 28 10 2021
entrez: 21 5 2020
Statut: ppublish

Résumé

Low-dose CT screening can reduce lung cancer-related mortality. However, CT screening has an FDR of nearly 96%. We sought to assess whether urine samples can be a source for DNA methylation-based detection of non-small cell lung cancer (NSCLC). This nested case-control study of subjects with suspicious nodules on CT imaging obtained plasma and urine samples preoperatively. Cases ( DNA methylation at cancer-specific loci was detected in both plasma and urine, and was more frequent in patients with cancer compared with controls for all six genes in plasma and in DNA methylation-based biomarkers in plasma and urine could be useful as an adjunct to CT screening to guide decision-making regarding further invasive procedures in patients with pulmonary nodules.

Identifiants

DOI: 10.1158/1078-0432.CCR-19-2896 PMID: 32430478 PMC: PMC7442601
pubmed: 32430478
pii: 1078-0432.CCR-19-2896
doi: 10.1158/1078-0432.CCR-19-2896
pmc: PMC7442601
mid: NIHMS1596827
doi:

Substances chimiques

Biomarkers, Tumor 0
Homeodomain Proteins 0
SOX17 protein, human 0
SOXF Transcription Factors 0
TAC1 protein, human 0
Tachykinins 0
homeobox protein HOXA9 0
CDO1 protein, human EC 1.13.11.20
Cysteine Dioxygenase EC 1.13.11.20

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

4339-4348

Subventions

Organisme : NCI NIH HHS
ID : U01 CA214165
Pays : United States

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Bin Liu (B)

Cancer Center, University of Illinois at Chicago, Chicago, Illinois.

Julio Ricarte Filho (J)

Cancer Center, University of Illinois at Chicago, Chicago, Illinois.

Apurva Mallisetty (A)

Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Cassandra Villani (C)

Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Anastasia Kottorou (A)

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Clinical and Molecular Oncology Laboratory, Medical School, University of Patras, Patras, Greece.

Kristen Rodgers (K)

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Chen Chen (C)

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.

Tomoaki Ito (T)

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Surgery, Juntendo University Shizuoka Hospital, Juntendo University School of Medicine, Shizuoka, Japan.

Kyla Holmes (K)

Cancer Center, University of Illinois at Chicago, Chicago, Illinois.

Nicole Gastala (N)

Department of Family Medicine, Mile Square Health Center, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Klara Valyi-Nagy (K)

Department of Pathology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Odile David (O)

Department of Pathology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Ron C Gaba (RC)

Department of Radiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Christian Ascoli (C)

Department of Pulmonary, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Mary Pasquinelli (M)

Department of Pulmonary, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Lawrence E Feldman (LE)

Department of Hematology and Oncology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Malek G Massad (MG)

Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Tza-Huei Wang (TH)

Department of Biomedical Engineering and Institute for Nano Biotechnology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland.

Ignacio Jusue-Torres (I)

Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois.

Enrico Benedetti (E)

Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Robert A Winn (RA)

Cancer Center, University of Illinois at Chicago, Chicago, Illinois.
Department of Pulmonary, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

Malcolm V Brock (MV)

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland.

James G Herman (JG)

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. ahulbert@uic.edu hermanj3@upmc.edu.

Alicia Hulbert (A)

Cancer Center, University of Illinois at Chicago, Chicago, Illinois. ahulbert@uic.edu hermanj3@upmc.edu.
Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Cysteine dioxygenase › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Diagnostic › Diagnostic précoce › Dépistage précoce du cancer › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-F › Detection of Promoter DNA Methylation in Urine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Kinines › Tachykinines › Detection of Promoter DNA Methylation in Urine...