Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.
contraction
oxytocin
preterm birth
tocolysis
uterus
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
21
5
2020
medline:
15
12
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
Magnesium sulfate is used as a tocolytic, but clinical efficacy has been seriously questioned. Our objective was to use controlled ex vivo conditions and known pregnancy stages, to investigate how 2 key factors, hormones and gestation, affect magnesium's tocolytic ability. We hypothesized that these factors could underlie the varying clinical findings around magnesium's efficacy. Myometrial strips were obtained from nonpregnant (n = 10), mid-pregnant (n = 12), and term-pregnant (n = 11) mouse uterus. The strips were mounted in organ baths superfused with oxygenated physiological saline at pH 7.4 and 37 °C. The effect of different concentrations of MgSO
Identifiants
pubmed: 32430707
doi: 10.1007/s43032-020-00185-8
pii: 10.1007/s43032-020-00185-8
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Oxytocin
50-56-6
Magnesium Sulfate
7487-88-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1570-1579Références
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