Oocyte retrieval outcomes among adolescent transgender males.
Assisted reproductive technology
Cisgender females
Fertility preservation
Oocyte cryopreservation
Transgender males
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
21
03
2020
accepted:
10
05
2020
pubmed:
21
5
2020
medline:
11
3
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
To compare fertility preservation (FP) outcomes among adolescent transgender males with those of cisgender females. This retrospective cohort study included nine adolescent transgender males and 39 adolescent cisgender females who underwent FP between January 2017-April 2019 and September 2013-April 2019, respectively. The transgender males were referred before initiating testosterone, and the cisgender females were referred due to cancer diagnosis before starting anticancer treatment. Statistical analyses compared assisted reproductive technology (ART) data and FP outcomes between two groups. Basal FSH levels (5.4 ± 1.7 mIU/mL) and AFC (19.8 ± 5.6) of all transgender males were normal compared with standard references. The mean age of transgender males and cisgender females was similar (16.4 ± 1.1 vs 15.5 ± 1.3 years, respectively, P = 0.064). The amount of FSH used for stimulation was significantly lower among the former compared with the latter (2416 ± 1041 IU vs 4372 ± 1877 IU, P < 0.001), but the duration of stimulation was similar (12.6 ± 4.0 and 10.1 ± 2.8 days, P = 0.086). Peak estradiol level was significantly higher among transgender males compared with cisgender females (3073 ± 2637 pg/mL vs 1269 ± 975 pg/mL, respectively, P = 0.018), but there were no significant differences in number of retrieved oocytes between the two groups (30.6 ± 12.8 vs 22 ± 13.2, P = 0.091), number of MII oocytes (25.6 ± 12.9 vs 18.8 ± 11.2, P = 0.134), or maturity rates (81.5 ± 10.0% vs 85.4 ± 14.6%, P = 0.261). Adolescent transgender males have an excellent response to ovulation stimulation before initiating testosterone treatment. Oocyte cryopreservation is, therefore, a feasible and effective way for them to preserve their fertility for future biological parenting.
Identifiants
pubmed: 32430731
doi: 10.1007/s10815-020-01815-5
pii: 10.1007/s10815-020-01815-5
pmc: PMC7376795
doi:
Substances chimiques
Estradiol
4TI98Z838E
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1737-1744Références
J Sex Med. 2011 Jun;8(6):1686-93
pubmed: 21477021
Hum Reprod. 2003 Oct;18(10):2169-74
pubmed: 14507840
Fertil Steril. 2012 Oct;98(4):957-60
pubmed: 22763097
Nature. 1990 Feb 22;343(6260):774-8
pubmed: 2154702
LGBT Health. 2019 Apr;6(3):107-115
pubmed: 30985275
Int Rev Psychiatry. 2016;28(1):112-9
pubmed: 26835612
J Sex Med. 2018 May;15(5):757-767
pubmed: 29699760
Eur J Obstet Gynecol Reprod Biol. 2010 Apr;149(2):175-7
pubmed: 20074845
Hum Reprod. 2007 Apr;22(4):1011-6
pubmed: 17166864
Fertil Steril. 2011 Feb;95(2):588-91
pubmed: 20542508
Reprod Health. 2018 Oct 25;15(1):181
pubmed: 30359260
Fertil Steril. 2009 Apr;91(4 Suppl):1476-8
pubmed: 18804204
Endocr Pract. 2020 Apr;26(4):423-428
pubmed: 32045294
Obstet Gynecol. 2017 Jun;129(6):1031-1034
pubmed: 28486372
J Clin Endocrinol Metab. 2017 Nov 1;102(11):3869-3903
pubmed: 28945902
Arq Bras Endocrinol Metabol. 2010 Aug;54(6):567-71
pubmed: 20857063
Am Fam Physician. 2013 Jan 15;87(2):89-93
pubmed: 23317072
Fertil Steril. 2010 Jun;94(1):149-55
pubmed: 19406395
Hum Reprod. 2001 Jan;16(1):145-147
pubmed: 11139553
J Ovarian Res. 2014 Dec 20;7:114
pubmed: 25526766
J Homosex. 2012;59(3):321-36
pubmed: 22455323
J Adolesc Health. 2019 May;64(5):589-593
pubmed: 30691936
Fertil Steril. 2015 Nov;104(5):1111-5
pubmed: 26363388
J Sex Med. 2009 Apr;6(4):1018-1023
pubmed: 18331254
Arch Sex Behav. 2020 Feb;49(2):421-432
pubmed: 31975034
Histopathology. 1991 Nov;19(5):445-52
pubmed: 1757084
Hum Reprod. 2004 Jan;19(1):41-7
pubmed: 14688154
Hum Reprod. 2015 Jun;30(6):1365-74
pubmed: 25908658
J Adolesc Health. 2020 Jun;66(6):750-753
pubmed: 32001141
J Clin Endocrinol Metab. 1989 Jul;69(1):151-7
pubmed: 2471710
J Adolesc Health. 2018 Jul;63(1):62-68
pubmed: 29503031
Int J Clin Oncol. 2019 Jan;24(1):28-33
pubmed: 29502284
Hum Mol Genet. 2014 Jan 15;23(2):333-41
pubmed: 24009315
Fertil Steril. 2010 Feb;93(3):865-8
pubmed: 19013563
Obstet Gynecol. 2015 Mar;125(3):605-10
pubmed: 25730222
Fertil Steril. 2018 Dec;110(7):1347-1355
pubmed: 30503134
J Adolesc Health. 2017 Jul;61(1):120-123
pubmed: 28363716
Front Horm Res. 2019;53:1-17
pubmed: 31499494
Hum Reprod. 1998 Jul;13(7):1837-40
pubmed: 9740435
J Sex Res. 2004 Feb;41(1):75-81
pubmed: 15216426
Hum Reprod Update. 2016 Nov;22(6):687-708
pubmed: 27511809
J Sex Med. 2014 Mar;11(3):720-8
pubmed: 24274329
Psychoneuroendocrinology. 2018 Dec;98:161-167
pubmed: 30165284
Sci Rep. 2015 Sep 11;5:13983
pubmed: 26358501
Hum Reprod. 2013 Feb;28(2):453-61
pubmed: 23188113
J Clin Endocrinol Metab. 2006 Oct;91(10):3885-90
pubmed: 16882752
Clin Endocrinol (Oxf). 2010 Feb;72(2):214-31
pubmed: 19473181
J Adolesc Health. 2017 Jul;61(1):40-44
pubmed: 28161526
Curr Pharm Biotechnol. 2012 Mar;13(3):426-34
pubmed: 21658000
Fertil Steril. 2015 May;103(5):1340-5
pubmed: 25772768
Maturitas. 2018 Jan;107:92-96
pubmed: 29169588
Hum Reprod Update. 2017 Jul 1;23(4):421-432
pubmed: 28531286
Fertil Steril. 2019 Nov;112(5):858-865
pubmed: 31594633
Fertil Steril. 2012 Apr;97(4):930-4
pubmed: 22283969
Eur Psychiatry. 2012 Aug;27(6):445-50
pubmed: 20620022
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6749-6753
pubmed: 30886089
J Assist Reprod Genet. 2019 Oct;36(10):2155-2161
pubmed: 31435820
Hum Reprod. 2017 Mar 1;32(3):568-574
pubmed: 28122888
Transgend Health. 2016 Jan 01;1(1):41-44
pubmed: 29159296
Clin Endocrinol (Oxf). 1993 Mar;38(3):325-9
pubmed: 8458105
J Adolesc Health. 2015 Oct;57(4):374-80
pubmed: 26208863
J Clin Endocrinol Metab. 1986 Jan;62(1):16-21
pubmed: 3940265
J Assist Reprod Genet. 2019 Sep;36(9):1837-1843
pubmed: 31327130
J Assist Reprod Genet. 2009 Sep-Oct;26(9-10):503-10
pubmed: 19866355