BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice.
Animals
Brain-Derived Neurotrophic Factor
/ genetics
Diabetes Mellitus, Type 2
/ genetics
Eating
/ genetics
Gene Expression Regulation
/ genetics
Glucose Tolerance Test
Glucose Transporter Type 4
/ genetics
Humans
Hypothalamus
/ metabolism
Insulin
/ metabolism
Mice
Obesity
/ genetics
Overweight
/ genetics
Polymorphism, Single Nucleotide
/ genetics
Sirtuin 1
/ genetics
BDNF Val66Met polymorphism
food intake
glucose metabolism
leptin
overweight
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
30
01
2020
revised:
09
04
2020
accepted:
01
05
2020
pubmed:
21
5
2020
medline:
7
4
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain-derived neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphism (SNP) and obesity, although the underlying mechanisms of this connection are still not completely understood. In the present study, we found that homozygous knock-in BDNF
Substances chimiques
Bdnf protein, mouse
0
Brain-Derived Neurotrophic Factor
0
Glucose Transporter Type 4
0
Insulin
0
Slc2a4 protein, mouse
0
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9667-9675Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007). Mouse and rat BDNF gene structure and expression revisited. Journal of Neuroscience Research, 85, 525-535.
Amadio, P., Colombo, G. I., Tarantino, E., Gianellini, S., Ieraci, A., Brioschi, M., … Barbieri, S. S. (2017). BDNFVal66met polymorphism: A potential bridge between depression and thrombosis. European Heart Journal, 38, 1426-1435.
Baj, G., Del Turco, D., Schlaudraff, J., Torelli, L., Deller, T., & Tongiorgi, E. (2013). Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: A systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus, 23, 413-423.
Baj, G., Leone, E., Chao, M. V., & Tongiorgi, E. (2011). Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments. Proceedings of the National Academy of Sciences of USA, 108, 16813-16818.
Bariohay, B., Lebrun, B., Moyse, E., & Jean, A. (2005). Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology, 146, 5612-20.
Bost, F., & Kaminski, L. (2019). The metabolic modulator PGC-1α in cancer. American Journal of Cancer Research, 9, 198-211.
Buie, J. J., Watson, L. S., Smith, C. J., & Sims-Robinson, C. (2019). Obesity-related cognitive impairment: The role of endothelial dysfunction. Neurobiology of Disease, 132, 104580.
Cakir, I., Perello, M., Lansari, O., Messier, N. J., Vaslet, C. A., & Nillni, E. A. (2009). Hypothalamic Sirt1 regulates food intake in a rodent model system. PLOS One, 4, e8322.
Camerino, C., Zayzafoon, M., Rymaszewski, M., Heiny, J., Rios, M., & Hauschka, P. V. (2012). Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype. Endocrinology, 153, 5394-5405.
Chen, Z. Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C. J., … Lee, F. S. (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science, 314, 140-143.
Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Marks, D. L., & Low, M. J. (2001). The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. International Journal of Obesity and Related Metabolic Disorders, 25(Suppl. 5), S63-7.
Da Dalt, L., Ruscica, M., Bonacina, F., Balzarotti, G., Dhyani, A., Di Cairano, E., … Norata, G. D. (2019). PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: The role of the low-density lipoprotein receptor. European Heart Journal, 40, 357-368.
Dincheva, I., Glatt, C. E., & Lee, F. S. (2012). Impact of the BDNF Val66Met polymorphism on cognition. Neuroscience, 18, 439-451.
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., … Weinberger, D. R. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-69.
El-Sayed Moustafa, J. S., & Froguel, P. (2013). From obesity genetics to the future of personalized obesity therapy. Nature Reviews Endocrinology, 9, 402-413.
Harvey, J. (2007). Leptin regulation of neuronal excitability and cognitive function. Current Opinion in Pharmacology, 6, 643-647.
Huan, J.-N., Li, J., Han, Y., Chen, K., Wu, N., & Zhao, A. Z. (2003). Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. Journal of Biological Chemistry, 278, 45638-50.
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000). BDNF regulates eating behavior and locomotor activity in mice. EMBO Journal, 19, 1290-1300.
Komori, T., Morikawa, Y., Nanjo, K., & Senba, E. (2006). Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience, 139, 1107-15.
Krabbe, K. S., Nielsen, A. R., Krogh-Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., … Pedersen, B. K. (2007). Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia, 50, 431-438.
Leal, G., Bramham, C. R., & Duarte, C. B. (2017). BDNF and hippocampal synaptic plasticity. Vitamins and Hormones, 104, 153-195.
Liao, G. Y., An, J. J., Gharami, K., Waterhouse, E. G., Vanevski, F., Jones, K. R., & Xu, B. (2012). Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nature Medicine, 18, 564-571.
Lommatzsch, M., Zingler, D., Schuhbaeck, K., Schloetcke, K., Zingler, C., Schuff-Werner, P., & Virchow, J. C. (2005). The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiology of Aging, 26, 115-123.
Lyons, M. R., & West, A. E. (2011). Mechanisms of specificity in neuronal activity-regulated gene transcription. Progress in Neurobiology, 94, 259-295.
Macchi, C., Steffani, L., Oleari, R., Lettieri, A., Valenti, L., Dongiovanni, P., … Ruscica, M. (2017). Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms. Molecular and Cellular Endocrinology, 454, 135-145.
Mallei, A., Baj, G., Ieraci, A., Corna, S., Musazzi, L., Lee, F. S., … Popoli, M. (2015). Expression and dendritic trafficking of BDNF-6 splice variant are impaired in knock-in mice carrying human BDNF Val66Met polymorphism. International Journal of Neuropsychopharmacology, 18, 1-10.
Mallei, A., Ieraci, A., Corna, S., Tardito, D., Lee, F. S., & Popoli, M. (2018). Global epigenetic analysis of BDNF Val66Met mice hippocampus reveals changes in dendrite and spine remodeling genes. Hippocampus, 28, 783-795.
Mallei, A., Ieraci, A., & Popoli, M. (2019). Chronic social defeat stress differentially regulates the expression of BDNF transcripts and epigenetic modifying enzymes in susceptible and resilient mice. World Journal of Biological Psychiatry, 20, 555-566.
Mariani, S., Costantini, D., Lubrano, C., Basciani, S., Caldaroni, C., Barbaro, G., … Gnessi, L. (2016). Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity. Nutrition, Metabolism and Cardiovascular Diseases, 26, 1033-1038.
Mariani, S., Fiore, D., Basciani, S., Persichetti, A., Contini, S., Lubrano, C., … Gnessi, L. (2015). Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. Endocrine, 49, 711-6.
Mariani, S., di Giorgio, M. R., Martini, P., Persichetti, A., Barbaro, G., Basciani, S., … Gnessi, L. (2018). Inverse association of circulating SIRT1 and adiposity: A study on underweight, normal weight, and obese patients. Frontiers in Endocrinology, 9, 449.
Moraes-Vieira, P. M., Saghatelian, A., & Kahn, B. B. (2016). GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-inflammatory effects. Diabetes, 65(7), 1808-1815.
Musazzi, L., Rimland, J. M., Ieraci, A., Racagni, G., Domenici, E., & Popoli, M. (2014). Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. International Journal of Neuropsychopharmacology, 17, 779-791.
Nakagomi, A., Okada, S., Yokoyama, M., Yoshida, Y., Shimizu, I., Miki, T., … Minamino, T. (2015). Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. NPJ Aging and Mechanisms of Disease, 1, 15009.
Notaras, M., Du, X., Gogos, J., van denBuuse, M., & Hill, R. A. (2017). The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair. Translational Psychiatry, 7, e1233.
Notaras, M., Hill, R., & van denBuuse, M. (2015). The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: Progress and controversy. Molecular Psychiatry, 20, 916-930.
Numakawa, T., Odaka, H., & Adachi, N. (2018). Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases. International Journal of Molecular Sciences, 19, 3650.
Pearson-Leary, J., & McNay, E. C. (2016). Novel roles for the insulin-regulated glucose transporter-4 in hippocampally dependent memory. Journal of Neuroscience, 36, 11851-11864.
Pillai, A., Bruno, D., Sarreal, A. S., Hernando, R. T., Saint-Louis, L. A., Nierenberg, J., … Buckley, P. F. (2012). Plasma BDNF levels vary in relation to body weight in females. PLOS One, 7, e39358.
Pivac, N., Kim, B., Nedić, G., Joo, Y. H., Kozarić-Kovačić, D., Hong, J. P., & Muck-Seler, D. (2009). Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy participants. Croatian Medical Journal, 50, 43-48.
Priego, T., Sánchez, J., Palou, A., & Picó, C. (2009). Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: Depot- and sex-related differential response. Genes and Nutrition, 4, 151-6.
Rios, M. (2013). BDNF and the central control of feeding: Accidental bystander or essential player? Trends Neurosci, 36, 83-90.
Saito, S., Watanabe, K., Hashimoto, E., & Saito, T. (2009). Low serum BDNF and food intake regulation: A possible new explanation of the pathophysiology of eating disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33, 312-316.
Sandrini, L., Ieraci, A., Amadio, P., Popoli, M., Tremoli, E., & Barbieri, S. S. (2017). Apocynin prevents abnormal megakaryopoiesis and platelet activation induced by chronic stress. Oxidative Medicine and Cellular Longevity, 2017, 1-12.
Sandrini, L., Ieraci, A., Amadio, P., Veglia, F., Popoli, M., Lee, F. S., … Barbieri, S. S. (2018). Sub-chronic stress exacerbates the pro-thrombotic phenotype in BDNFVal/Met mice: Gene-environment interaction in the modulation of arterial thrombosis. International Journal of Molecular Sciences, 19, 3235.
Sandrini, L., Ieraci, A., Amadio, P., Zarà, M., Mitro, N., Lee, F. S., … Barbieri, S. S. (2019). Physical exercise affects adipose tissue profile and prevents arterial thrombosis in BDNF Val66Met mice. Cells, 8, 875.
Sandrini, L., Di Minno, A., Amadio, P., Ieraci, A., Tremoli, E., & Barbieri, S. (2018). Association between obesity and circulating brain-derived neurotrophic factor (BDNF) levels: Systematic review of literature and meta-analysis. International Journal of Molecular Sciences, 19, 2281.
Séron, K., Corset, L., Vasseur, F., Boutin, P., Gómez-Ambrosi, J., Salvador, J., … Froguel, P. (2006). Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochemical and Biophysical Research Communications, 348, 1232-8.
Sestan-Pesa, M., & Horvath, T. L. (2016). Metabolism and mental illness. Trends in Molecular Medicine, 22(2), 174-183.
Shimizu, E., Hashimoto, K., & Iyo, M. (2004). Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits. American Journal of Medical Genetics, 126B, 122-123.
Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007). Relationship between adipocyte size and adipokine expression and secretion. Journal of Clinical Endocrinology and Metabolism, 92, 1023-1033.
Suwa, M., Yamamoto, K.-I., Nakano, H., Sasaki, H., Radak, Z., & Kumagai, S. (2010). Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice. Physiological Research, 59, 619-23.
Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., … Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, 100160.
Unger, T. J., Calderon, G. A., Bradley, L. C., Sena-Esteves, M., & Rios, M. (2007). Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. Journal of Neuroscience, 27, 14265-14274.
Valassi, E., Scacchi, M., & Cavagnini, F. (2008). Neuroendocrine control of food intake. Nutrition, Metabolism & Cardiovascular Diseases, 18, 158-168.
Valet, P., Grujic, D., Wade, J., Ito, M., Zingaretti, M. C., Soloveva, V., … Lowell, B. B. (2000). Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. Journal of Biological Chemistry, 275, 34797-802.
Wang, D. D., Tian, T., Dong, Q., Xu, X. F., Yu, H., Wang, Y., & Chen, Z. Y. (2014). Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system. Hippocampus, 24, 65-78.
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., … Reichardt, L. F. (2003). Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nature Neuroscience, 6, 736-742.
Yang, X., Brobst, D., Chan, W. S., Tse, M. C. L., Herlea-Pana, O., Ahuja, P., … Chan, C. B. (2019). Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility. Science Signaling, 12. eaau1468.
Yeo, G. S. H., Connie Hung, C.-C., Rochford, J., Keogh, J., Gray, J., Sivaramakrishnan, S., … Farooqi, I. S. (2004). A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nature Neuroscience, 7, 1187-9.
Yu, H., Wang, D.-D., Wang, Y., Liu, T., Lee, F. S., & Chen, Z.-Y. (2012). Variant brain-derived neurotrophic factor val66met polymorphism alters vulnerability to stress and response to antidepressants. Journal of Neuroscience, 32, 4092-4101.