Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers.
canine hip dysplasia
genotyping
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
accepted:
20
04
2020
pubmed:
21
5
2020
medline:
21
11
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
617-619Subventions
Organisme : The Danish Kennel Club
Informations de copyright
© 2020 Stichting International Foundation for Animal Genetics.
Références
Bartolomé N., Segarra S., Artieda M.et al. (2015) A genetic predictive model for canine hip dysplasia: integration of genome wide association study (GWAS) and candidate gene approaches. PLoS ONE 10, e0122558.
Bennett D. & May C. (1995) Joint diseases of dogs and cats. In: Textbook of Veterinary Internal Medicine, 4th edn (Ed. by S.J. Ettinger & E.C. Feldman), pp. 2047. W.B. Saunders Company, Philadelphia, PA.
Corley E.A., Keller G.G., Lattimer J.C. & Ellersiek M.R. (1997) Reliability of early radiographic evaluations for canine hip dysplasia obtained from the standard ventrodorsal radiographic projection. Journal of the American Veterinary Medical Association 211, 1142-6.
Fels L. & Distl O. (2014) Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd dogs. PLoS ONE 9, e96618.
Ginja M., Gaspar A.R. & Ginja C. (2015) Emerging insights into the genetic basis of canine hip dysplasia. Veterinary Medicine: Research and Reports 6, 193-202.
King M.D. (2017) Etiopathogenesis of canine hip dysplasia, prevalence, and genetics. Veterinary Clinics: Small Animal Practice 47, 753-67.
Lavrijsen I.C.M., Leegwater P.A.J., Martin A.J., Harris S.J., Tryfonidou M.A., Heuven H.C.M. & Hazewinkel H.A.W. (2014) Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers. PLoS ONE 9, e87735.
Mikkola L.I., Holopainen S., Lappalainen A.K., Pessa-Morikawa T., Augustine T.J.P., Arumilli M., Hytönen M.K., Hakosalo O., Lohi H. & Livanainen A. (2019) Novel protective and risk loci in hip dysplasia in German Shepherds. PLoS Genetics 15, e1008197.
Oberbauer A.M., Keller G.G. & Famula T.R. (2017) Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds. PLoS ONE 12, e0172918.
Riser W.H. (1975) The dysplastic hip joint: radiologic and histologic development. Veterinary Pathology 12, 279-305.
Sánchez-Molano E., Woolliams J.A., Pong-Wong R., Clements D.N., Blott S.C. & Wiener P. (2014) Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers. BMC Genomics 15, 833.
Wood J.L. & Lakhani K.H. (2003) Hip dysplasia in Labrador Retrievers: the effects of age at scoring. Veterinary Record 152, 37-40.