Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture.
Alkaloids
/ pharmacology
Amaryllidaceae Alkaloids
/ pharmacology
Animals
Antiviral Agents
/ pharmacology
Betacoronavirus
/ drug effects
Cell Survival
/ drug effects
Chlorocebus aethiops
Chloroquine
/ pharmacology
Deoxycytidine
/ analogs & derivatives
Dose-Response Relationship, Drug
Drug Combinations
Drug Synergism
Phenanthridines
/ pharmacology
SARS-CoV-2
Vero Cells
Virus Replication
/ drug effects
Gemcitabine
2019-nCoV
Novel coronavirus
SARS-CoV-2
alkaloid
broad-spectrum antiviral
Journal
Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
21
5
2020
medline:
13
6
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture. We found that all three tested compounds inhibited viral replication in Vero-E6 cells at noncytotoxic concentrations. The antiviral effect of gemcitabine was suppressed efficiently by the cytidine nucleosides. Additionally, combination of gemcitabine with oxysophoridine had an additive antiviral effect against SARS-CoV-2. Our results demonstrate that broad-spectrum antiviral compounds may have a priority for the screening of antiviral compounds against newly emerging viruses to control viral infection.
Identifiants
pubmed: 32432977
doi: 10.1080/22221751.2020.1772676
pmc: PMC7448857
doi:
Substances chimiques
Alkaloids
0
Amaryllidaceae Alkaloids
0
Antiviral Agents
0
Drug Combinations
0
Phenanthridines
0
oxysophoridine
0
Deoxycytidine
0W860991D6
Chloroquine
886U3H6UFF
lycorine
I9Q105R5BU
Gemcitabine
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
1170-1173Références
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