Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation.


Journal

Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742

Informations de publication

Date de publication:
01 2021
Historique:
received: 17 09 2019
accepted: 23 04 2020
revised: 06 04 2020
pubmed: 21 5 2020
medline: 13 10 2021
entrez: 21 5 2020
Statut: ppublish

Résumé

Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these candidate microbes actively modulate host phenotypes or passively expand within the altered microbial ecosystem is frequently not known. Here we demonstrate that colonization of mice with a member of the genus Prevotella, which has been previously associated to colitis in mice, exacerbates intestinal inflammation. Our analysis revealed that Prevotella intestinalis alters composition and function of the ecosystem resulting in a reduction of short-chain fatty acids, specifically acetate, and consequently a decrease in intestinal IL-18 levels during steady state. Supplementation of IL-18 to Prevotella-colonized mice was sufficient to reduce intestinal inflammation. Hence, we conclude that intestinal Prevotella colonization results in metabolic changes in the microbiota, which reduce IL-18 production and consequently exacerbate intestinal inflammation, and potential systemic autoimmunity.

Identifiants

pubmed: 32433514
doi: 10.1038/s41385-020-0296-4
pii: S1933-0219(22)00112-X
pmc: PMC7790746
doi:

Substances chimiques

Cytokines 0
Inflammation Mediators 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113-124

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Auteurs

Aida Iljazovic (A)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Urmi Roy (U)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Eric J C Gálvez (EJC)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.
Hannover Medical School, Hannover, Germany.

Till R Lesker (TR)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Bei Zhao (B)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Achim Gronow (A)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Lena Amend (L)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.

Sabine E Will (SE)

Bacterial Metabolomics, Leibniz institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.

Julia D Hofmann (JD)

Department of Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Braunschweig, Germany.

Marina C Pils (MC)

Mouse Pathology, Helmholtz Center for Infection Research, Braunschweig, Germany.

Kerstin Schmidt-Hohagen (K)

Department of Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Braunschweig, Germany.

Meina Neumann-Schaal (M)

Bacterial Metabolomics, Leibniz institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.

Till Strowig (T)

Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany. till.strowig@helmholtz-hzi.de.
Hannover Medical School, Hannover, Germany. till.strowig@helmholtz-hzi.de.
Centre for Individualised Infection Medicine, Hannover, Germany. till.strowig@helmholtz-hzi.de.

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