Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation.
Adaptive Immunity
Animals
Bacteroidaceae Infections
/ immunology
Cytokines
/ metabolism
Disease Models, Animal
Disease Susceptibility
Gastrointestinal Microbiome
/ immunology
Host-Pathogen Interactions
/ immunology
Inflammation Mediators
/ metabolism
Intestinal Mucosa
/ immunology
Metagenome
Metagenomics
/ methods
Mice
Mice, Knockout
Mucositis
/ etiology
Prevotella
/ immunology
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
17
09
2019
accepted:
23
04
2020
revised:
06
04
2020
pubmed:
21
5
2020
medline:
13
10
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these candidate microbes actively modulate host phenotypes or passively expand within the altered microbial ecosystem is frequently not known. Here we demonstrate that colonization of mice with a member of the genus Prevotella, which has been previously associated to colitis in mice, exacerbates intestinal inflammation. Our analysis revealed that Prevotella intestinalis alters composition and function of the ecosystem resulting in a reduction of short-chain fatty acids, specifically acetate, and consequently a decrease in intestinal IL-18 levels during steady state. Supplementation of IL-18 to Prevotella-colonized mice was sufficient to reduce intestinal inflammation. Hence, we conclude that intestinal Prevotella colonization results in metabolic changes in the microbiota, which reduce IL-18 production and consequently exacerbate intestinal inflammation, and potential systemic autoimmunity.
Identifiants
pubmed: 32433514
doi: 10.1038/s41385-020-0296-4
pii: S1933-0219(22)00112-X
pmc: PMC7790746
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-124Références
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