Vascular Regeneration in Peripheral Artery Disease.
Angiogenesis Inducing Agents
/ therapeutic use
Animals
Arteries
/ drug effects
Cytokines
/ therapeutic use
Humans
Neovascularization, Physiologic
/ drug effects
Peripheral Arterial Disease
/ metabolism
Recovery of Function
Regeneration
/ drug effects
Regional Blood Flow
Stem Cell Transplantation
Treatment Outcome
morbidity
mortality
myocardial infarction
peripheral artery disease
stroke
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
22
5
2020
medline:
8
10
2020
entrez:
22
5
2020
Statut:
ppublish
Résumé
Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only modest effects on limb blood flow. Accordingly, there is an opportunity to develop medical approaches to restore limb perfusion. Vascular regeneration to enhance limb blood flow includes methods to enhance angiogenesis, arteriogenesis, and vasculogenesis using angiogenic cytokines and cell therapies. We review the molecular mechanisms of these processes; briefly discuss what we have learned from the clinical trials of angiogenic and cell therapies; and conclude with an overview of a potential new approach based upon transdifferentiation to enhance vascular regeneration in peripheral artery disease.
Identifiants
pubmed: 32434408
doi: 10.1161/ATVBAHA.120.312862
pmc: PMC7357605
mid: NIHMS1593955
doi:
Substances chimiques
Angiogenesis Inducing Agents
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1627-1634Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133254
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148338
Pays : United States
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