DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
Adjuvants, Immunologic
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Betacoronavirus
/ immunology
Bronchoalveolar Lavage Fluid
/ virology
COVID-19
COVID-19 Vaccines
Coronavirus Infections
/ immunology
Disease Models, Animal
Female
Humans
Immunity, Cellular
Immunity, Humoral
Immunization, Secondary
Immunogenicity, Vaccine
Immunologic Memory
Macaca mulatta
Male
Mutant Proteins
/ chemistry
Nasal Mucosa
/ virology
Pandemics
/ prevention & control
Pneumonia, Viral
/ immunology
Protein Domains
SARS-CoV-2
Spike Glycoprotein, Coronavirus
/ chemistry
Vaccination
Vaccines, DNA
/ administration & dosage
Viral Load
Viral Vaccines
/ administration & dosage
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
05
05
2020
accepted:
16
05
2020
pubmed:
22
5
2020
medline:
28
8
2020
entrez:
22
5
2020
Statut:
ppublish
Résumé
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log
Identifiants
pubmed: 32434945
pii: science.abc6284
doi: 10.1126/science.abc6284
pmc: PMC7243363
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Mutant Proteins
0
Spike Glycoprotein, Coronavirus
0
Vaccines, DNA
0
Viral Vaccines
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
806-811Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI110700
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007151
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139538
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108197
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146779
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121394
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI149644
Pays : United States
Organisme : NIH HHS
ID : R01 OD024917
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100625
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129797
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132178
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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