Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
03
2020
accepted:
29
04
2020
entrez:
22
5
2020
pubmed:
22
5
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot neuroarthropathy. HbA1c levels and other relevant data were extracted from medical databases of 44 cases of acute Charcot neuroarthropathy. HbA1c levels significantly declined from 8.25% (67mmol/mol) [7.1%-9.4%](54-79mmol/mol), at -6 months (M-6), to 7.40%(54mmol/mol) [6.70%-8.03%] (50-64 mmol/mol) during the six months preceding the diagnosis of Charcot neuroarthropathy (P <0.001). HbA1c levels significantly declined during the six months preceding the onset of Charcot neuroarthropathy. This decline seems to be a associated factor with the appearance of an active phase of Charcot neuroarthropathy in poorly controlled patients with diabetic sensitive neuropathy.
Identifiants
pubmed: 32437409
doi: 10.1371/journal.pone.0233168
pii: PONE-D-20-06583
pmc: PMC7241699
doi:
Substances chimiques
Glycated Hemoglobin A
0
Hypoglycemic Agents
0
hemoglobin A1c protein, human
0
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0233168Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Diab Rep. 2005 Dec;5(6):430-5
pubmed: 16316593
J Diabetes Complications. 2019 Dec;33(12):107438
pubmed: 31668589
Diabet Med. 1996;13 Suppl 1:S52-4
pubmed: 8741831
Diabetologia. 2002 Aug;45(8):1085-96
pubmed: 12189438
Swiss Med Wkly. 2014 Apr 24;144:w13948
pubmed: 24764120
Brain. 2015 Jan;138(Pt 1):43-52
pubmed: 25392197
J Am Podiatr Med Assoc. 2014 Sep-Oct;104(5):522-5
pubmed: 25275743
Exp Clin Endocrinol Diabetes. 2012 Jun;120(6):335-9
pubmed: 22421981
Diabetes Care. 2000 Jun;23(6):796-800
pubmed: 10840999
Clin Transplant. 2015 Aug;29(8):712-9
pubmed: 26033225
Diabetologia. 2008 Jun;51(6):1035-40
pubmed: 18389210
Zhonghua Yi Xue Za Zhi. 2007 May 15;87(18):1234-7
pubmed: 17686254
Curr Diab Rep. 2017 Oct 24;17(12):127
pubmed: 29064042
Bone Joint J. 2016 Sep;98-B(9):1155-9
pubmed: 27587513
Acta Orthop. 2015;86(4):415-25
pubmed: 25811776