Lipid Metabolism and Axon Degeneration: An ACOX1 Balancing Act.

Acyl-CoA Oxidase / genetics Axons Gain of Function Mutation Lipid Metabolism Mutation

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
20 05 2020
Historique:
entrez: 22 5 2020
pubmed: 22 5 2020
medline: 18 8 2020
Statut: ppublish

Résumé

The loss of peroxisomal function has been implicated in many neurodegenerative diseases, yet the underlying molecular mechanisms are poorly understood. In this issue of Neuron, Chung et al. (2020) demonstrate that gain- and loss-of-function mutations in the peroxisomal acyl-CoA oxidase 1 (ACOX1) gene cause neurodegeneration via distinct molecular pathways in glia.

Identifiants

DOI: 10.1016/j.neuron.2020.04.030 PMID: 32437651
pubmed: 32437651
pii: S0896-6273(20)30343-3
doi: 10.1016/j.neuron.2020.04.030
pii:
doi:

Substances chimiques

Acyl-CoA Oxidase EC 1.3.3.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

551-553

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Emily N Griffin (EN)

Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Program, University of California San Diego, La Jolla, CA 92093, USA.

Susan L Ackerman (SL)

Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093, USA; Section of Neurobiology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: sackerman@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Flavoprotéines › Acyl-CoA oxidase › Lipid Metabolism and Axon Degeneration: An...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Lipid Metabolism and Axon Degeneration: An...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation gain de fonction › Lipid Metabolism and Axon Degeneration: An...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Lipid Metabolism and Axon Degeneration: An...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Lipid Metabolism and Axon Degeneration: An...