Aluminum exposure promotes the metastatic proclivity of human colorectal cancer cells through matrix metalloproteinases and the TGF-β/Smad signaling pathway.
Aluminum Chloride
/ toxicity
Colorectal Neoplasms
/ enzymology
Epithelial-Mesenchymal Transition
/ drug effects
HT29 Cells
Humans
Matrix Metalloproteinase 7
/ metabolism
Matrix Metalloproteinase 8
/ metabolism
Neoplasm Metastasis
Signal Transduction
/ drug effects
Smad2 Protein
/ metabolism
Smad3 Protein
/ metabolism
Transforming Growth Factor beta
/ metabolism
Aluminum
Angiogenesis
Human colorectal cancer cells
Matrix metalloproteinases
Metastasis
TGF-β/Smad
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
13
03
2020
revised:
30
04
2020
accepted:
30
04
2020
pubmed:
22
5
2020
medline:
20
2
2021
entrez:
22
5
2020
Statut:
ppublish
Résumé
Human exposure to aluminum (Al) mainly occurs through food intake. However, influences of Al on the gastrointestinal tract have been rarely reported. In particular, the effect of Al on the metastasis and angiogenesis of colorectal cancer cells has not been studied. Thus, we investigated the effect of Al on the metastatic proclivity using the human colorectal cancer cell line, HT-29. Cells were exposed to 1-16 mM AlCl
Identifiants
pubmed: 32437896
pii: S0278-6915(20)30290-8
doi: 10.1016/j.fct.2020.111402
pii:
doi:
Substances chimiques
SMAD2 protein, human
0
SMAD3 protein, human
0
Smad2 Protein
0
Smad3 Protein
0
Transforming Growth Factor beta
0
Aluminum Chloride
3CYT62D3GA
MMP7 protein, human
EC 3.4.24.23
Matrix Metalloproteinase 7
EC 3.4.24.23
MMP8 protein, human
EC 3.4.24.34
Matrix Metalloproteinase 8
EC 3.4.24.34
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111402Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.