Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume.

Amygdala Combat Disorders Humans Male Stress Disorders, Post-Traumatic Telomere Veterans
Amygdala Autonomic nervous system Combat trauma PTSD Stress Telomere length

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285

Informations de publication

Date de publication:
07 2020
Historique:
received: 06 01 2020
revised: 06 03 2020
accepted: 20 03 2020
pubmed: 23 5 2020
medline: 10 3 2021
entrez: 23 5 2020
Statut: ppublish

Résumé

Traumatic stress can adversely affect physical and mental health through neurobiological stress response systems. We examined the effects of trauma exposure and posttraumatic stress disorder (PTSD) on telomere length, a biomarker of cellular aging, and volume of the amygdala, a key structure of stress regulation, in combat-exposed veterans. In addition, the relationships of psychopathological symptoms and autonomic function with telomere length and amygdala volume were examined. Male combat veterans were categorized as having PTSD diagnosis (n = 102) or no lifetime PTSD diagnosis (n = 111) based on the Clinician-Administered PTSD Scale. Subjects were assessed for stress-related psychopathology, trauma severity, autonomic function, and amygdala volumes by magnetic resonance imaging. A significant interaction was found between trauma severity and PTSD status for telomere length and amygdala volume after adjusting for multiple confounders. Subjects with PTSD showed shorter telomere length and larger amygdala volume than those without PTSD among veterans exposed to high trauma, while there was no significant group difference in these parameters among those exposed to low trauma. Among veterans exposed to high trauma, greater telomere shortening was significantly correlated with greater norepinephrine, and larger amygdala volume was correlated with more severe psychological symptoms and higher heart rates. These data suggest that the intensity of the index trauma event plays an important role in interacting with PTSD symptomatology and autonomic activity in predicting telomere length and amygdala volume. These results highlight the importance of trauma severity and PTSD status in predicting certain biological outcomes.

Sections du résumé

BACKGROUND
Traumatic stress can adversely affect physical and mental health through neurobiological stress response systems. We examined the effects of trauma exposure and posttraumatic stress disorder (PTSD) on telomere length, a biomarker of cellular aging, and volume of the amygdala, a key structure of stress regulation, in combat-exposed veterans. In addition, the relationships of psychopathological symptoms and autonomic function with telomere length and amygdala volume were examined.
METHODS
Male combat veterans were categorized as having PTSD diagnosis (n = 102) or no lifetime PTSD diagnosis (n = 111) based on the Clinician-Administered PTSD Scale. Subjects were assessed for stress-related psychopathology, trauma severity, autonomic function, and amygdala volumes by magnetic resonance imaging.
RESULTS
A significant interaction was found between trauma severity and PTSD status for telomere length and amygdala volume after adjusting for multiple confounders. Subjects with PTSD showed shorter telomere length and larger amygdala volume than those without PTSD among veterans exposed to high trauma, while there was no significant group difference in these parameters among those exposed to low trauma. Among veterans exposed to high trauma, greater telomere shortening was significantly correlated with greater norepinephrine, and larger amygdala volume was correlated with more severe psychological symptoms and higher heart rates.
CONCLUSIONS
These data suggest that the intensity of the index trauma event plays an important role in interacting with PTSD symptomatology and autonomic activity in predicting telomere length and amygdala volume. These results highlight the importance of trauma severity and PTSD status in predicting certain biological outcomes.

Identifiants

DOI: 10.1016/j.bpsc.2020.03.007 PMID: 32439402
pubmed: 32439402
pii: S2451-9022(20)30076-8
doi: 10.1016/j.bpsc.2020.03.007
pii:
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

678-687

Investigateurs

Leroy Hood (L)
Kerry J Ressler (KJ)
Daniel Lindqvist (D)
Ji Hoon Cho (JH)
Michelle Coy (M)
Frank Desarnaud (F)
Francesco Saverio Bersani (FS)
Silvia Fossati (S)
Allison Hoke (A)
Raina Kumar (R)
Meng Li (M)
Iouri Makotkine (I)
Stacy-Ann Miller (SA)
Linda Petzold (L)
Laura Price (L)
Meng Qian (M)
Kelsey Scherler (K)
Seshamalini Srinivasan (S)
Anna Suessbrick (A)
Li Tang (L)
Xiaogang Wu (X)
David Baxter (D)
Esther Blessing (E)
Kelsey R Dean (KR)
Bernie J Daigle (BJ)
Guia Guffanti (G)
Kai Wang (K)
Lynn M Almli (LM)
F Nabarun Chakraborty (FN)
Duncan Donohue (D)
Kimberly Kerley (K)
Taek-Kyun Kim (TK)
Eugene Laska (E)
Inyoul Lee (I)
Min Young Lee (MY)
Adriana Lori (A)
Liangqun Lu (L)
Burook Misganaw (B)
Seid Muhie (S)
Jennifer Newman (J)
Nathan Price (N)
Shizhen Qin (S)
Carole Siegel (C)
Pramod R Somvanshi (PR)
Gunjan S Thakur (GS)
Young Zhou (Y)
Ruoting Yang (R)

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. All rights reserved.

Auteurs

Jee In Kang (JI)

Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California; Institute of Behavioral Science in Medicine and Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: jeeinkang@yuhs.ac.

Susanne G Mueller (SG)

Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.

Gwyneth W Y Wu (GWY)

Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California.

Jue Lin (J)

Department of Biochemistry and Biophysics, University of California, San Francisco School of Medicine, San Francisco, California.

Peter Ng (P)

Center for Imaging of Neurodegenerative Diseases, VA Medical Center San Francisco, San Francisco, California.

Rachel Yehuda (R)

James J. Peters VA Medical Center, Bronx, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Janine D Flory (JD)

James J. Peters VA Medical Center, Bronx, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Duna Abu-Amara (D)

Steven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University School of Medicine, New York, New York.

Victor I Reus (VI)

Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California.

Aarti Gautam (A)

Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Fort Detrick, Maryland.

Rasha Hammamieh (R)

Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Fort Detrick, Maryland.

Francis J Doyle (FJ)

Harvard John A. Paulson School of Engineering & Applied Sciences, Harvard University, Cambridge, Massachusetts.

Marti Jett (M)

Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Fort Detrick, Maryland.

Charles R Marmar (CR)

Steven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University School of Medicine, New York, New York.

Synthia H Mellon (SH)

Department of OB-GYN and Reproductive Sciences, University of California, San Francisco School of Medicine, San Francisco, California.

Owen M Wolkowitz (OM)

Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Effect of Combat Exposure and Posttraumatic...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles psychiques liés à la guerre › Effect of Combat Exposure and Posttraumatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of Combat Exposure and Posttraumatic...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Effect of Combat Exposure and Posttraumatic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Effect of Combat Exposure and Posttraumatic...
questionsmedicales.fr › Personnes › Anciens combattants › Effect of Combat Exposure and Posttraumatic...