Effect of intracerebroventricular administration of two molecular forms of sulfated CCK octapeptide on anxiety-like behavior in the zebrafish danio rerio.
Animals
Anxiety
/ chemically induced
Behavior, Animal
/ drug effects
Benzodiazepines
/ pharmacology
Brain
/ metabolism
Carbolines
/ pharmacology
Injections, Intraventricular
Locomotion
/ drug effects
Proglumide
/ pharmacology
Sincalide
/ administration & dosage
Zebrafish
Zebrafish Proteins
/ metabolism
Anxiety-like behavior
Brain
CCK-like immunoreactivity
CCKA-8s
CCKB-8s
Cholecystokinin
ICV administration
Preference test
Zebrafish
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
10
04
2020
revised:
11
05
2020
accepted:
13
05
2020
pubmed:
24
5
2020
medline:
10
6
2021
entrez:
24
5
2020
Statut:
ppublish
Résumé
Cholecystokinin octapeptide with sulfate (CCK-8s) regulates feeding behavior and psychomotor activity. In rodents and goldfish, intracerebroventricular (ICV) injection of CCK-8s decreases food intake and also induces anxiety-like behavior. The zebrafish has several merits for investigating the psychophysiological roles of neuropeptides. However, little is known about the brain localization of CCK and the behavioral action of CCK-8s in this species. Here we investigated the brain localization of CCK-like immunoreactivity and found that it was distributed throughout the brain. As CCK-like immunoreactivity was particularly evident in the ventral habenular nucleus, the interpeduncular nucleus and superior raphe, we subsequently examined the effect of zebrafish (zf) CCK-8s on psychomotor control. Since the zebrafish possesses two molecular forms of zfCCK-8s (zfCCKA-8s and zfCCKB-8s), two synthetic peptides were administered intracerebroventricularly at 1, 5 and 10 pmol g
Identifiants
pubmed: 32445877
pii: S0196-9781(20)30079-6
doi: 10.1016/j.peptides.2020.170330
pii:
doi:
Substances chimiques
8-sulfocholecystokinin octapeptide
0
Carbolines
0
Zebrafish Proteins
0
Benzodiazepines
12794-10-4
FG 7142
60PO70N1BP
Proglumide
EPL8W5565D
Sincalide
M03GIQ7Z6P
tofisopam
UZC80HAU42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170330Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflicts of interest.