Weathering the Storm: Managing Older Adults With Breast Cancer Amid COVID-19 and Beyond.


Journal

Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089

Informations de publication

Date de publication:
06 04 2021
Historique:
received: 07 04 2020
revised: 18 05 2020
accepted: 20 05 2020
pubmed: 26 5 2020
medline: 4 5 2021
entrez: 26 5 2020
Statut: ppublish

Résumé

Caring for older patients with breast cancer presents unique clinical considerations because of preexisting and competing comorbidity, the potential for treatment-related toxicity, and the consequent impact on functional status. In the context of the COVID-19 pandemic, treatment decision making for older patients is especially challenging and encourages us to refocus our treatment priorities. While we work to avoid treatment delays and maintain therapeutic benefit, we also need to minimize the risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposures, myelosuppression, general chemotherapy toxicity, and functional decline. Herein, we propose multidisciplinary care considerations for the aging patient with breast cancer, with the goal to promote a team-based, multidisciplinary treatment approach during the COVID-19 pandemic and beyond. These considerations remain relevant as we navigate the "new normal" for the approximately 30% of breast cancer patients aged 70 years and older who are diagnosed in the United States annually and for the thousands of older patients living with recurrent and/or metastatic disease.

Identifiants

pubmed: 32449757
pii: 5843796
doi: 10.1093/jnci/djaa079
pmc: PMC7313961
doi:

Substances chimiques

ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

355-359

Subventions

Organisme : NCI NIH HHS
ID : K12 CA001727
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA227615
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Auteurs

Rachel A Freedman (RA)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Mina S Sedrak (MS)

Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.

Jennifer R Bellon (JR)

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.

Caroline C Block (CC)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Nancy U Lin (NU)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Tari A King (TA)

Department of Surgery, Division of Breast Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Christina Minami (C)

Department of Surgery, Division of Breast Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Noam VanderWalde (N)

Department of Radiation Oncology, West Cancer Center and Research Institute, University of Tennessee Health Science Center, Memphis, TN, USA.

Trevor A Jolly (TA)

Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.

Hyman B Muss (HB)

Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.

Eric P Winer (EP)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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