Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities.
Cardiac lymphatic dysfunction
Cardiac metabolism
Coronary microvascular dysfunction
Heart failure with preserved ejection fraction
Inflammation
Myocardial fibrosis
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
25 05 2020
25 05 2020
Historique:
received:
02
04
2020
accepted:
13
05
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
10
7
2021
Statut:
epublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specific prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fibrosis, inflammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade inflammation have been proposed to participate in HFpEF development. Furthermore, several recent studies demonstrated the occurrence of generalized lymphatic dysfunction in experimental models of risk factors for HFpEF, including obesity, hypercholesterolaemia, type 2 diabetes mellitus (T2DM), hypertension, and aging. Here, we review the evidence for a combined role of coronary (micro)vascular dysfunction and lymphatic vessel alterations in mediating key pathological steps in HFpEF, including reduced cardiac perfusion, chronic low-grade inflammation, and myocardial oedema, and their impact on cardiac metabolic alterations (oxygen and nutrient supply/demand imbalance), fibrosis, and cardiomyocyte stiffness. We focus primarily on HFpEF caused by metabolic risk factors, such as obesity, T2DM, hypertension, and aging.
Identifiants
pubmed: 32451732
doi: 10.1007/s00395-020-0798-y
pii: 10.1007/s00395-020-0798-y
pmc: PMC7248044
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
39Subventions
Organisme : European Research Area Network Cardiovascular disease
ID : LYMIT-DIS 2016
Pays : International
Organisme : European Research Area Network Cardiovascular disease
ID : Macro ERA 2016
Pays : International
Organisme : Fonds Wetenschappelijk Onderzoek
ID : GOH7716N
Pays : International
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1160718N
Pays : International
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G091018N
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 16-ECVD-0004
Pays : International
Organisme : Stichting voor de Technische Wetenschappen
ID : ZonMw 2016T091
Pays : International
Organisme : Stichting voor de Technische Wetenschappen
ID : Vidi 91796338
Pays : International
Organisme : Instituto de Salud Carlos III
ID : AC16/00020
Pays : International
Organisme : Instituto de Salud Carlos III
ID : CB16/11/00483
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI18/01469
Pays : International
Organisme : Narodowe Centrum Badań i Rozwoju
ID : ERA-CVD/LyMitDis/1/2017
Pays : International
Organisme : Hartstichting
ID : CVON2016-Early HFPEF, 2015-10
Pays : International
Organisme : Hartstichting
ID : CVON She-PREDICTS, grant 2017-21
Pays : International
Organisme : ontrat de Plan État-Région - Fonds Européen de Développement Régional
ID : CPER/FEDER 2015 (DO-IT)
Pays : International
Organisme : ontrat de Plan État-Région - Fonds Européen de Développement Régional
ID : CPER/FEDER 2016 (PACT-CBS)
Pays : International
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