The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.
bifunctional enzymes
biochemical pathways
covalent modification cycles
localization
spatial organization
two-component systems
Journal
Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Biochemical pathways and networks are central to cellular information processing. While a broad range of studies have dissected multiple aspects of information processing in biochemical pathways, the effect of spatial organization remains much less understood. It is clear that space is central to intracellular organization, plays important roles in cellular information processing and has been exploited in evolution; additionally, it is being increasingly exploited in synthetic biology through the development of artificial compartments, in a variety of ways. In this paper, we dissect different aspects of the interplay between spatial organization and biochemical pathways, by focusing on basic building blocks of these pathways: covalent modification cycles and two-component systems, with enzymes which may be monofunctional or bifunctional. Our analysis of spatial organization is performed by examining a range of 'spatial designs': patterns of localization or non-localization of enzymes/substrates, theoretically and computationally. Using these well-characterized
Identifiants
pubmed: 32453980
doi: 10.1098/rsif.2020.0251
pmc: PMC7276544
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20200251Références
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