Lipid metabolism of the oleaginous yeast Lipomyces starkeyi.
Acyl-CoA synthesis pathway
Breeding
Lipid metabolism
Lipomyces starkeyi
Oleaginous yeast
Triacylglycerol
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
30
03
2020
accepted:
18
05
2020
revised:
13
05
2020
pubmed:
28
5
2020
medline:
25
2
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
The oleaginous yeast Lipomyces starkeyi is an excellent sustainable lipid producer, which can convert industrial wastes into lipids and accumulate triacylglycerols (TAG) by > 70% of its dry cell weight. Recent studies using omics technologies applied in L. starkeyi have aided in obtaining greater understanding of the important mechanisms of lipid metabolism in L. starkeyi. Therefore, the development of genetic engineering tools for L. starkeyi has led to accelerated efforts for a highly efficient production of lipids.This review focuses on the aspects of TAG and fatty acid synthesis pathways in L. starkeyi. We also present a quite effective strategy to obtain L. starkeyi mutants accumulating a larger amount of lipids and having a higher lipid production rate than the wild-type strain. The analysis of these mutants exhibiting high lipid production has led to the identification of important genes for achieving highly effective lipid production and thus advanced improvement in lipid production. Herein, our aim was to provide useful information to advance the development of L. starkeyi as a cost-effective TAG feedstock.Key Points•Oleaginous yeast Lipomyces starkeyi is an excellent sustainable lipid producer.•Efficient isolation of lipid-enriched L. starkeyi mutants depends on the low density of lipids.•Increased acyl-CoA synthesis pathway is important for improving lipid productivity.
Identifiants
pubmed: 32458138
doi: 10.1007/s00253-020-10695-9
pii: 10.1007/s00253-020-10695-9
doi:
Substances chimiques
Fatty Acids
0
Triglycerides
0
Fatty Acid Desaturases
EC 1.14.19.-
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6141-6148Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K05401
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