Remyelination alters the pattern of myelin in the cerebral cortex.
astrocyte
axon
cortex
mouse
multiple sclerosis
myelin
neuroscience
oligodendrocyte
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
27 05 2020
27 05 2020
Historique:
received:
04
03
2020
accepted:
22
05
2020
pubmed:
28
5
2020
medline:
16
3
2021
entrez:
28
5
2020
Statut:
epublish
Résumé
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin can be restored by regenerating oligodendrocytes from resident progenitors; however, it is not known whether regeneration restores the complex myelination patterns in cortical circuits. Here, we performed time lapse in vivo two photon imaging in somatosensory cortex of adult mice to define the kinetics and specificity of myelin regeneration after acute oligodendrocyte ablation. These longitudinal studies revealed that the pattern of myelination in cortex changed dramatically after regeneration, as new oligodendrocytes were formed in different locations and new sheaths were often established along axon segments previously lacking myelin. Despite the dramatic increase in axonal territory available, oligodendrogenesis was persistently impaired in deeper cortical layers that experienced higher gliosis. Repeated reorganization of myelin patterns in MS may alter circuit function and contribute to cognitive decline.
Identifiants
pubmed: 32459173
doi: 10.7554/eLife.56621
pii: 56621
pmc: PMC7292648
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P30 NS050274
Pays : United States
Organisme : NIH HHS
ID : NS080153
Pays : United States
Organisme : NIH HHS
ID : NS051509
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS091018
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS041435
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS041435
Pays : United States
Organisme : NIH HHS
ID : NS050274
Pays : United States
Informations de copyright
© 2020, Orthmann-Murphy et al.
Déclaration de conflit d'intérêts
JO, CC, GM, YH, MR No competing interests declared, PC PI on grants to JHU from Biogen and Annexon and has received consulting fees for serving on scientific advisory boards for Biogen and Disarm Therapeutics. 1147, DB Reviewing editor, eLife
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