COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - Is there any scientific evidence for controversy?
ACEIs/ARBs
COVID-19
RAAS
SARS coronavirus (CoV)-2
angiotensin-converting enzyme 2 (ACE2)
cardiovascular system
pandemic
Journal
Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
03
2020
revised:
08
05
2020
accepted:
12
05
2020
pubmed:
28
5
2020
medline:
30
9
2020
entrez:
28
5
2020
Statut:
ppublish
Résumé
Renin-angiotensin system (RAS) blockers are extensively used worldwide to treat many cardiovascular disorders, where they are effective in reducing both mortality and morbidity. These drugs are known to induce an increased expression of angiotensin-converting enzyme 2 (ACE2). ACE2 acts as receptor for the novel SARS coronavirus-2 (SARS-CoV-2) which raising the important issue of possible detrimental effects that RAS blockers could exert on the natural history and pathogenesis of the coronavirus disease-19 (COVID-19) and associated excessive inflammation, myocarditis and cardiac arrhythmias. We review the current knowledge on the interaction between SARS-CoV-2 infection and RAS blockers and suggest a scientific rationale for continuing RAS blockers therapy in patients with COVID-19 infection.
Identifiants
pubmed: 32459372
doi: 10.1111/joim.13101
pmc: PMC7283873
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
410-421Subventions
Organisme : European and Developing Countries Clinical Trials Partnership the EU Horizon 2020 Framework Programme for Research and Innovation
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Association for the Publication of the Journal of Internal Medicine.
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