Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.
Adult
Aged
Anti-Bacterial Agents
/ therapeutic use
Bacteria
/ classification
Carbapenems
/ therapeutic use
Cephalosporins
/ therapeutic use
Clostridioides difficile
/ drug effects
Diarrhea
/ epidemiology
Enterocolitis, Pseudomembranous
/ drug therapy
Female
Gastrointestinal Microbiome
/ genetics
Humans
India
/ epidemiology
Male
Metagenomics
Middle Aged
Rural Population
Urban Population
Young Adult
Clostridioides difficile
Central India
Gut microbiome
antibiotic resistome
diarrhea
virome
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
pubmed:
28
5
2020
medline:
1
10
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal diseases, particularly We observed distinct rural-urban differences in bacterial and viral populations, with geography exhibiting a greater influence than diarrheal status. We report distinct differences in antimicrobial resistance gene profiles, enrichment of metabolic pathways and phage composition between rural and urban populations, as well as a higher burden of
Sections du résumé
BACKGROUND
The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal diseases, particularly
RESULTS
We observed distinct rural-urban differences in bacterial and viral populations, with geography exhibiting a greater influence than diarrheal status.
CONCLUSIONS
We report distinct differences in antimicrobial resistance gene profiles, enrichment of metabolic pathways and phage composition between rural and urban populations, as well as a higher burden of
Identifiants
pubmed: 32459982
doi: 10.1080/19490976.2020.1752605
pmc: PMC7781581
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Cephalosporins
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1752605Subventions
Organisme : Department of Health
Pays : United Kingdom
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