Dietary bioaccumulation potential of silver nanomaterials compared to silver nitrate in wistar rats using an ex vivo gut sac technique.
3Rs
Alternative methods
Bioavailability
Gut exposure
Rapid testing
Silver sulphide nanoparticles
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
23
03
2020
revised:
11
05
2020
accepted:
12
05
2020
pubmed:
28
5
2020
medline:
24
7
2020
entrez:
28
5
2020
Statut:
ppublish
Résumé
Chronic dietary bioaccumulation tests with rodents are required for new substances, including engineered nanomaterials (ENMs), in order to provide information on the potential hazards to human health. However, screening tools are needed to manage the diversity of ENMs and alternative methods are desirable with respect to animal welfare. Here, an ex vivo gut sac method was used to estimate the dietary bioaccumulation potential of silver nanomaterials. The entire gastrointestinal tract (except the caecum) was removed and filled with a gut saline containing 1 mg L
Identifiants
pubmed: 32460051
pii: S0147-6513(20)30584-4
doi: 10.1016/j.ecoenv.2020.110745
pii:
doi:
Substances chimiques
Silver Compounds
0
Silver
3M4G523W1G
Silver Nitrate
95IT3W8JZE
silver sulfide
9ZB10YHC1C
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110745Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interests The authors have no interests to declare.