Job insecurity and risk of coronary heart disease: Mediation analyses of health behaviors, sleep problems, physiological and psychological factors.
Adult
Allostasis
/ physiology
Coronary Disease
/ epidemiology
Employment
/ psychology
Female
Health Behavior
/ physiology
Humans
Incidence
Male
Mediation Analysis
Middle Aged
Risk Factors
Sleep
/ physiology
Sleep Wake Disorders
/ epidemiology
Stress, Psychological
/ complications
Surveys and Questionnaires
United Kingdom
/ epidemiology
Allostatic load
Cardiovascular disease
Depressive symptoms
Job insecurity
Mechanisms
Sleep
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
13
08
2019
revised:
21
04
2020
accepted:
29
04
2020
pubmed:
28
5
2020
medline:
5
6
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
Job insecurity has been linked to increased risk of coronary heart disease (CHD), but underlying mechanisms remain uncertain. Our aim was to assess the extent to which this association is mediated through life style, physiological, or psychological factors. A total of 3917 men and women free from CHD provided data on job insecurity in the Whitehall II cohort study in 1997-1999. The association between job insecurity and CHD was decomposed into a direct and indirect effect mediated through unhealthy behaviors (smoking, high alcohol consumption, physical inactivity), sleep disturbances, 'allostatic load', or psychological distress. The counterfactual analyses on psychological distress indicated a marginally significant association between job insecurity and incident CHD (hazard ratio (HR) 1.32; 95 % confidence interval (CI) 1.00-1.75). This association was decomposed into a direct (HR 1.22, 95 %CI 0.92-1.63) and indirect association (1.08, 95 %CI 1.01-1.15), suggesting that about 30 % of the total relationship was mediated by psychological distress. No mediation was indicated via health behaviors, sleep disturbances, or allostatic load, although job insecurity was related to disturbed sleep and C-reactive protein, which, in turn were associated with CHD. In conclusion, our results suggest that psychological distress may play a role in the relation between job insecurity and CHD.
Identifiants
pubmed: 32460194
pii: S0306-4530(20)30125-6
doi: 10.1016/j.psyneuen.2020.104706
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104706Subventions
Organisme : British Heart Foundation
ID : RG/16/11/32334
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/2/30098
Pays : United Kingdom
Organisme : Medical Research Council
ID : S011676
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/11/63/29011
Pays : United Kingdom
Organisme : Medical Research Council
ID : R024227
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG034454
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL036310
Pays : United States
Organisme : Medical Research Council
ID : K013351
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K013351/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG056477
Pays : United States
Organisme : British Heart Foundation
ID : PG/11/63/29011
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.