Dynamical in-situ observation of the lyophilization and vacuum-drying processes of a model biopharmaceutical system by an environmental scanning electron microscope.
Bovine serum albumin
Environmental scanning electron microscopy
Freeze-drying
Vacuum-drying
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jul 2020
30 Jul 2020
Historique:
received:
16
12
2019
revised:
23
04
2020
accepted:
18
05
2020
pubmed:
29
5
2020
medline:
4
3
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
The paper discusses the real-time monitoring of the changing sample morphology during the entire lyophilization (freeze-drying) and vacuum-drying processes of model biopharmaceutical solutions by using an environmental scanning electron microscope (ESEM); the device's micromanipulators were used to study the interior of the samples in-situ without exposing the samples to atmospheric water vapor. The individual collapse temperatures (T
Identifiants
pubmed: 32461002
pii: S0378-5173(20)30432-4
doi: 10.1016/j.ijpharm.2020.119448
pii:
doi:
Substances chimiques
Serum Albumin, Bovine
27432CM55Q
Sucrose
57-50-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119448Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.