Kidney replacement therapy in pediatric patients on mechanical circulatory support: challenges for the pediatric nephrologist.
Continuous kidney replacement therapy (CKRT)
Mechanical circulatory support (MCS)
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
02
03
2020
accepted:
06
05
2020
revised:
30
04
2020
pubmed:
29
5
2020
medline:
15
2
2022
entrez:
29
5
2020
Statut:
ppublish
Résumé
The use of mechanical circulatory support (MCS) therapies in children with medically refractory cardiac failure has increased over the past two decades. With the growing experience and expertise, MCS is currently offered as a bridge to recovery or heart transplantation and in some cases even as destination therapy. Acute kidney injury (AKI) is common in patients with end-stage heart failure (ESHF). When severe AKI develops requiring kidney replacement therapy (KRT), these patients present unique challenges for the pediatric nephrology team. The use of KRT has not been adequately described in children with ESHF on the newer MCS. We also present original case series data from our center experience. The purpose of this review is to familiarize the reader with the current MCS technologies, approach to their selection, how they interact when combined with current KRT circuits, and distinguish similarities and differences. We will attempt to highlight the distinctive features of each technology, specifically focusing on growing trends in use of continuous-flow ventricular assist devices (CF-VAD) as it poses additional challenges to the pediatric nephrologist.
Identifiants
pubmed: 32462258
doi: 10.1007/s00467-020-04605-4
pii: 10.1007/s00467-020-04605-4
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1109-1117Références
O’Connor MJ, Rossano JW (2014) Ventricular assist devices in children. Curr Opin Cardiol 29:113–121. https://doi.org/10.1097/HCO.0000000000000030
doi: 10.1097/HCO.0000000000000030
pubmed: 24270395
Wehman B, Stafford KA, Bittle GJ, Kon ZN, Evans CF, Rajagopal K, Pietris N, Kaushal S, Griffith BP (2016) Modern outcomes of mechanical circulatory support as a bridge to pediatric heart transplantation. Ann Thorac Surg 101:2321–2327. https://doi.org/10.1016/j.athoracsur.2015.12.003
doi: 10.1016/j.athoracsur.2015.12.003
pubmed: 26912304
pmcid: 5524136
Burki S, Adachi I (2017) Pediatric ventricular assist devices: current challenges and future prospects. Vasc Health Risk Manag 13:177–185. https://doi.org/10.2147/VHRM.S82379
doi: 10.2147/VHRM.S82379
pubmed: 28546755
pmcid: 5437969
Rossano JW, Cherikh WS, Chambers DC, Goldfarb S, Hayes D Jr, Khush KK, Kucheryavaya AY, Toll AE, Levvey BJ, Meiser B, Stehlik J (2018) The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-first pediatric heart transplantation report-2018; Focus theme: Multiorgan Transplantation. J Heart Lung Transplant 37:1184–1195. https://doi.org/10.1016/j.healun.2018.07.018
doi: 10.1016/j.healun.2018.07.018
pubmed: 30293614
Prodhan P, Bhutta AT, Gossett JM, Dodgen AL, Seib PM, Imamura M, Gupta P (2013) Comparative effects of ventricular assist device and extracorporeal membrane oxygenation on renal function in pediatric heart failure. Ann Thorac Surg 96:1428–1434. https://doi.org/10.1016/j.athoracsur.2013.05.083
doi: 10.1016/j.athoracsur.2013.05.083
pubmed: 23987896
May LJ, Montez-Rath ME, Yeh J, Axelrod DM, Chen S, Maeda K, Almond CS, Rosenthal DN, Hollander SA, Sutherland SM (2016) Impact of ventricular assist device placement on longitudinal renal function in children with end-stage heart failure. J Heart Lung Transplant 35:449–456. https://doi.org/10.1016/j.healun.2015.10.039
doi: 10.1016/j.healun.2015.10.039
pubmed: 26653933
Friedland-Little JM, Hong BJ, Gossett JG, Deshpande SR, Law S, Hollifield KA, Cantor RS, Koehl D, Kindel SJ, Turrentine MW, Davies RR (2018) Changes in renal function after left ventricular assist device placement in pediatric patients: a Pedimacs analysis. J Heart Lung Transplant 37:1218–1225. https://doi.org/10.1016/j.healun.2018.06.016
doi: 10.1016/j.healun.2018.06.016
pubmed: 30293616
Copeland JG, Copeland H, Gustafson M, Mineburg N, Covington D, Smith RG, Friedman M (2012) Experience with more than 100 total artificial heart implants. J Thorac Cardiovasc Surg 143:727–734. https://doi.org/10.1016/j.jtcvs.2011.12.002
doi: 10.1016/j.jtcvs.2011.12.002
pubmed: 22245242
Gorga SM, Sahay RD, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT (2020) Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy: a multicenter retrospective cohort study. Pediatr Nephrol 35:871–882. https://doi.org/10.1007/s00467-019-04468-4
doi: 10.1007/s00467-019-04468-4
pubmed: 31953749
Hansrivijit P, Lertjitbanjong P, Thongprayoon C, Cheungpasitporn W, Aeddula NR, Salim SA, Chewcharat A, Watthanasuntorn K, Srivali N, Mao MA, Ungprasert P, Wijarnpreecha K, Kaewput W, Bathini T (2019) Acute kidney injury in pediatric patients on extracorporeal membrane oxygenation: a systematic review and meta-analysis. Medicines (Basel) 6(4). https://doi.org/10.3390/medicines6040109
Ostermann M, Connor M Jr, Kashani K (2018) Continuous renal replacement therapy during extracorporeal membrane oxygenation: why, when and how? Curr Opin Crit Care 24:493–503. https://doi.org/10.1097/MCC.0000000000000559
doi: 10.1097/MCC.0000000000000559
pubmed: 30325343
Santhanakrishnan A, Nestle TT, Moore BL, Yoganathan AP, Paden ML (2013) Development of an accurate fluid management system for a pediatric continuous renal replacement therapy device. ASAIO J 59:294–301. https://doi.org/10.1097/MAT.0b013e31828ea5e2
doi: 10.1097/MAT.0b013e31828ea5e2
pubmed: 23644618
Zafar F, Jefferies JL, Tjossem CJ, Bryant R 3rd, Jaquiss RD, Wearden PD, Rosenthal DN, Cabrera AG, Rossano JW, Humpl T, Morales DL (2015) Biventricular Berlin Heart EXCOR pediatric use across the united states. Ann Thorac Surg 99:1328–1334. https://doi.org/10.1016/j.athoracsur.2014.09.078
doi: 10.1016/j.athoracsur.2014.09.078
pubmed: 25704863
Conway J, Miera O, Adachi I, Maeda K, Eghtesady P, Henderson HT, Guleserian K, Fan CS, Kirk R, Pediatric VAD Investigators (2018) Worldwide experience of a durable centrifugal flow pump in pediatric patients. Semin Thorac Cardiovasc Surg 30:327–335. https://doi.org/10.1053/j.semtcvs.2018.03.003
doi: 10.1053/j.semtcvs.2018.03.003
pubmed: 29551744
Ricci M, Gaughan CB, Rossi M, Andreopoulos FM, Novello C, Salerno TA, Rosenkranz ER, Panos AL (2008) Initial experience with the TandemHeart circulatory support system in children. ASAIO J 54:542–545. https://doi.org/10.1097/MAT.0b013e31818312f1
doi: 10.1097/MAT.0b013e31818312f1
pubmed: 18812750
Conway J, Al-Aklabi M, Granoski D, Islam S, Ryerson L, Anand V, Guerra G, Mackie AS, Rebeyka I, Buchholz H (2016) Supporting pediatric patients with short-term continuous-flow devices. J Heart Lung Transplant 35:603–609. https://doi.org/10.1016/j.healun.2016.01.1224
doi: 10.1016/j.healun.2016.01.1224
pubmed: 27009672
Almond CS, Buchholz H, Massicotte P, Ichord R, Rosenthal DN, Uzark K, Jaquiss RD, Kroslowitz R, Kepler MB, Lobbestael A, Bellinger D, Blume ED, Fraser CD Jr, Bartlett RH, Thiagarajan R, Jenkins K (2011) Berlin Heart EXCOR Pediatric ventricular assist device Investigational Device Exemption study: study design and rationale. Am Heart J 162(425-435):e426. https://doi.org/10.1016/j.ahj.2011.05.026
doi: 10.1016/j.ahj.2011.05.026
Adachi I (2018) Current status and future perspectives of the PumpKIN trial. Transl Pediatr 7:162–168. https://doi.org/10.21037/tp.2018.02.04
doi: 10.21037/tp.2018.02.04
pubmed: 29770297
pmcid: 5938249
Muth CM, Shank ES (2000) Gas embolism. N Engl J Med 342:476–482. https://doi.org/10.1056/NEJM200002173420706
doi: 10.1056/NEJM200002173420706
pubmed: 10675429
Patel AM, Adeseun GA, Ahmed I, Mitter N, Rame JE, Rudnick MR (2013) Renal failure in patients with left ventricular assist devices. Clin J Am Soc Nephrol 8:484–496. https://doi.org/10.2215/CJN.06210612
doi: 10.2215/CJN.06210612
pubmed: 23065497
Thomas BA, Logar CM, Anderson AE (2012) Renal replacement therapy in congestive heart failure requiring left ventricular assist device augmentation. Perit Dial Int 32:386–392. https://doi.org/10.3747/pdi.2011.00076
doi: 10.3747/pdi.2011.00076
pubmed: 22859837
pmcid: 3524848
Florescu MC, Sacks AR, Um JY (2015) Cardiac assist devices and hemodialysis catheter procedures - what do the nephrologists need to know? Semin Dial 28:670–675. https://doi.org/10.1111/sdi.12404
doi: 10.1111/sdi.12404
pubmed: 26133515
Fischbach M, Edefonti A, Schroder C, Watson A, European Pediatric Dialysis Working Group (2005) Hemodialysis in children: general practical guidelines. Pediatr Nephrol 20:1054–1066. https://doi.org/10.1007/s00467-005-1876-y
doi: 10.1007/s00467-005-1876-y
pubmed: 1766474
pmcid: 1766474
Jain SR, Smith L, Brewer ED, Goldstein SL (2001) Non-invasive intravascular monitoring in the pediatric hemodialysis population. Pediatr Nephrol 16:15–18
doi: 10.1007/s004670000504
Frazier OH, Myers TJ, Westaby S, Gregoric ID (2004) Clinical experience with an implantable, intracardiac, continuous flow circulatory support device: physiologic implications and their relationship to patient selection. Ann Thorac Surg 77:133–142. https://doi.org/10.1016/s0003-4975(03)01321-3
doi: 10.1016/s0003-4975(03)01321-3
pubmed: 14726049
Myers TJ, Bolmers M, Gregoric ID, Kar B, Frazier OH (2009) Assessment of arterial blood pressure during support with an axial flow left ventricular assist device. J Heart Lung Transplant 28:423–427. https://doi.org/10.1016/j.healun.2009.01.013
doi: 10.1016/j.healun.2009.01.013
pubmed: 19416768
Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, Starling RC, Chen L, Boyle AJ, Chillcott S, Adamson RM, Blood MS, Camacho MT, Idrissi KA, Petty M, Sobieski M, Wright S, Myers TJ, Farrar DJ, HeartMate II Clinical Investigators (2010) Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant 29(4 Suppl):S1–S39. https://doi.org/10.1016/j.healun.2010.01.011
doi: 10.1016/j.healun.2010.01.011
pubmed: 20181499
Schima H, Boehm H, Huber L, Schmallegger H, Vollkron M, Hiesmayr M, Noisser R, Wieselthaler G (2004) Automatic system for noninvasive blood pressure determination in rotary pump recipients. Artif Organs 28:451–457. https://doi.org/10.1111/j.1525-1594.2004.07095.x
doi: 10.1111/j.1525-1594.2004.07095.x
pubmed: 15113339
Bennett MK, Roberts CA, Dordunoo D, Shah A, Russell SD (2010) Ideal methodology to assess systemic blood pressure in patients with continuous-flow left ventricular assist devices. J Heart Lung Transplant 29:593–594. https://doi.org/10.1016/j.healun.2009.11.604
doi: 10.1016/j.healun.2009.11.604
pubmed: 20060321
Lanier GM, Orlanes K, Hayashi Y, Murphy J, Flannery M, Te-Frey R, Uriel N, Yuzefpolskaya M, Mancini DM, Naka Y, Takayama H, Jorde UP, Demmer RT, Colombo PC (2013) Validity and reliability of a novel slow cuff-deflation system for noninvasive blood pressure monitoring in patients with continuous-flow left ventricular assist device. Circ Heart Fail 6:1005–1012. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000186
doi: 10.1161/CIRCHEARTFAILURE.112.000186
pubmed: 23811966
Massicotte MP, Bauman ME, Murray J, Almond CS (2015) Antithrombotic therapy for ventricular assist devices in children: do we really know what to do? J Thromb Haemost 13(Suppl 1):S343–S350. https://doi.org/10.1111/jth.12928
doi: 10.1111/jth.12928
pubmed: 26149046
VanderPluym CJ, Cantor RS, Machado D, Boyle G, May L, Griffiths E, Niebler RA, Lorts A, Rossano J, Sutcliffe DL, Lytrivi ID, Buchholz H, Fynn-Thompson F, Hawkins B, Conway J (2019) Utilization and outcomes of children treated with direct thrombin inhibitors on paracorporeal ventricular assist device support. ASAIO J. https://doi.org/10.1097/MAT.0000000000001093
Teruya J, Hensch L, Bruzdoski K, Adachi I, Hui SR, Kostousov V (2020) Monitoring bivalirudin therapy in children on extracorporeal circulatory support devices: Thromboelastometry versus routine coagulation testing. Thromb Res 186:54–57. https://doi.org/10.1016/j.thromres.2019.12.007
doi: 10.1016/j.thromres.2019.12.007
pubmed: 31884000
Tsu LV, Dager WE (2011) Bivalirudin dosing adjustments for reduced renal function with or without hemodialysis in the management of heparin-induced thrombocytopenia. Ann Pharmacother 45:1185–1192. https://doi.org/10.1345/aph.1Q177
doi: 10.1345/aph.1Q177
pubmed: 21881032
Frontera JA, Lewin JJ 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL (2016) Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocrit Care 24:6–46. https://doi.org/10.1007/s12028-015-0222-x
doi: 10.1007/s12028-015-0222-x
pubmed: 26714677
Oudemans-van Straaten HM (2010) Citrate anticoagulation for continuous renal replacement therapy in the critically ill. Blood Purif 29:191–196. https://doi.org/10.1159/000245646
doi: 10.1159/000245646
pubmed: 20093826
Kreuzer M, Ahlenstiel T, Kanzelmeyer N, Ehrich JH, Pape L (2010) Management of regional citrate anticoagulation in pediatric high-flux dialysis: activated coagulation time versus post-filter ionized calcium. Pediatr Nephrol 25:1305–1310. https://doi.org/10.1007/s00467-010-1483-4
doi: 10.1007/s00467-010-1483-4
pubmed: 20221775