Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation.

Adenocarcinoma / drug therapy Antioxidants / pharmacology Carcinoma, Pancreatic Ductal / drug therapy Cell Hypoxia / drug effects Disease Progression Humans Pancreatic Stellate Cells / drug effects Resveratrol / pharmacology
PSCs hypoxia pancreatic cancer resveratrol stromal desmoplasia

Journal

Cell transplantation
ISSN: 1555-3892
Titre abrégé: Cell Transplant
Pays: United States
ID NLM: 9208854

Informations de publication

Date de publication:
Historique:
entrez: 29 5 2020
pubmed: 29 5 2020
medline: 29 6 2021
Statut: ppublish

Résumé

Pancreatic cancer is characterized by a hypoxic tumor microenvironment, which is primarily caused by massive fibrosis with pancreatic stellate cells (PSCs) as a main component. Our previous studies have shown that resveratrol can significantly inhibit pancreatic cancer. However, whether resveratrol can inhibit hypoxia-induced cancer development remains unclear. The objective of this study was to explore whether PSCs and hypoxia synergistically mediate aggressiveness in pancreatic cancer and detect the potential pleiotropic protective effects of resveratrol on hypoxia-induced pancreatic cancer progression. Human PSCs were treated with vehicle or resveratrol under normoxic or hypoxic conditions (3% O

Identifiants

DOI: 10.1177/0963689720929987 PMID: 32463297 PMC: PMC7563930
pubmed: 32463297
doi: 10.1177/0963689720929987
pmc: PMC7563930
doi:

Substances chimiques

Antioxidants 0
Resveratrol Q369O8926L

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

963689720929987

Commentaires et corrections

Type : ErratumIn

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Auteurs

Ying Xiao (Y)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Both the authors contributed equally to this article.

Tao Qin (T)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Both the authors contributed equally to this article.
ORCID: 0000-0002-7674-698X

Liankang Sun (L)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Weikun Qian (W)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Jie Li (J)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Wanxing Duan (W)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Jianjun Lei (J)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Zheng Wang (Z)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Jiguang Ma (J)

Department of Anesthesiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Xuqi Li (X)

Department of General Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Qingyong Ma (Q)

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Qinhong Xu (Q)

Department of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
ORCID: 0000-0003-0654-5290

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Cellules › Cellules stellaires pancréatiques › Resveratrol Ameliorates the Malignant...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Polyphénols › Resvératrol › Resveratrol Ameliorates the Malignant...