Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized
MRS
early detection
hyperpolarization
kinetic rate constant and modeling
metabolic imaging
metabolic plasticity and PanINs progression
metabolic rewiring
pancreatic cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 May 2020
25 May 2020
Historique:
received:
01
04
2020
revised:
20
05
2020
accepted:
22
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
18
2
2021
Statut:
epublish
Résumé
While pancreatic cancer (PC) survival rates have recently shown modest improvement, the disease remains largely incurable. Early detection of pancreatic cancer may result in improved outcomes and therefore, methods for early detection of cancer, even premalignant lesions, may provide more favorable outcomes. Pancreatic intraepithelial neoplasias (PanINs) have been identified as premalignant precursor lesions to pancreatic cancer. However, conventional imaging methods used for screening high-risk populations do not have the sensitivity to detect PanINs. Here, we have employed hyperpolarized metabolic imaging in vivo and nuclear magnetic resonance (
Identifiants
pubmed: 32466260
pii: ijms21103722
doi: 10.3390/ijms21103722
pmc: PMC7279395
pii:
doi:
Substances chimiques
Carbon Isotopes
0
L-Lactate Dehydrogenase
EC 1.1.1.27
Alanine Transaminase
EC 2.6.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218004
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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