Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice.

Animals Biomarkers Collaborative Cross Mice Cystatin C / genetics Female Mice Quantitative Trait Loci
Cystatin C Kidney biomarkers MPP Multi parental models Multiparent Advanced Generation Inter-Cross (MAGIC) Quantitative trait loci Type-I interferon signalling pathway multiparental populations

Journal

G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598

Informations de publication

Date de publication:
07 07 2020
Historique:
pubmed: 30 5 2020
medline: 22 6 2021
entrez: 30 5 2020
Statut: epublish

Résumé

Plasma concentration of Cystatin C (CysC) level is a biomarker of glomerular filtration rate in the kidney. We use a Systems Genetics approach to investigate the genetic determinants of plasma CysC concentration. To do so we perform Quantitative Trait Loci (QTL) and expression QTL (eQTL) analysis of 120 Diversity Outbred (DO) female mice, 56 weeks of age. We performed network analysis of kidney gene expression to determine if the gene modules with common functions are associated with kidney biomarkers of chronic kidney diseases. Our data demonstrates that plasma concentrations and kidney mRNA levels of CysC are associated with genetic variation and are transcriptionally coregulated by immune genes. Specifically, Type-I interferon signaling genes are coexpressed with

Identifiants

DOI: 10.1534/g3.120.401275 PMID: 32467129 PMC: PMC7341122
pubmed: 32467129
pii: g3.120.401275
doi: 10.1534/g3.120.401275
pmc: PMC7341122
doi:

Substances chimiques

Biomarkers 0
Cystatin C 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2529-2541

Subventions

Organisme : NIH HHS
ID : U42 OD010924
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG038070
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133169
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128572
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025786
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021801
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK114502
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES022845
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES031007
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK099442
Pays : United States

Informations de copyright

Copyright © 2020 Huda et al.

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Auteurs

M Nazmul Huda (MN)

Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, USDA, ARS, Davis, California 95616.
Department of Nutrition, University of California Davis, California 95616.
ORCID: 0000-0003-2775-4470

Melissa VerHague (M)

Nutrition Research Institute, University of North Carolina Kannapolis, North Carolina 28081.

Jody Albright (J)

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599.

Tangi Smallwood (T)

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599.

Timothy A Bell (TA)

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599.

Excel Que (E)

Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, USDA, ARS, Davis, California 95616.

Darla R Miller (DR)

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599.

Baback Roshanravan (B)

Department of Medicine, Division of Nephrology, University of California, Davis, Davis, California 95616, and.

Hooman Allayee (H)

Departments of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles California 90033.

Fernando Pardo Manuel de Villena (FP)

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599.
ORCID: 0000-0002-5738-5795

Brian J Bennett (BJ)

Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, USDA, ARS, Davis, California 95616, brian.bennett@ars.usda.gov.
Department of Nutrition, University of California Davis, California 95616.
ORCID: 0000-0002-0766-3195

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dissecting the Genetic Architecture of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Dissecting the Genetic Architecture of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris du Collaborative Cross › Dissecting the Genetic Architecture of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Cystatines › Cystatine C › Dissecting the Genetic Architecture of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dissecting the Genetic Architecture of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Dissecting the Genetic Architecture of...